进行性系统性硬化症肺功能测定的意义  

The value of pulmonary function measurements in progressive systemic Sclerosis

作　　者：茌璐琪[1] 刘又宁[1] 

机构地区：[1]解放军总医院呼吸科

出　　处：《军医进修学院学报》1997年第1期43-44,共2页Academic Journal of Pla Postgraduate Medical School

摘　　要：进行性系统性硬化症（ＰＳＳ）常合并肺间质改变导致呼吸功能障碍，为了解肺功能测定在ＰＳＳ中的意义，本文将４２例ＰＳＳ患者按其不同的胸片表现分为３组，将各组肺功能结果进行比较。结果发现在胸片正常或仅表现为肺纹理增强的大部分患者中，肺弥散能力（ＤＬｃｏ）已有明显异常，小气道功能也已出现异常，而且这些变化可出现在肺容积下降及Ｘ线改变之前，提示小气道功能及弥散功能测定是ＰＳＳ患者肺部损害的早期敏感指标。Pulmonary function measurements were performed in 42 patients with progressive systemic sclerosis (PSS) to determine the value of pulmonary function test in patient with PSS. According to roentgenologic evidences of chest film, patients with PSS were divided into 3 groups, and the pulmonary function data were prepared between these 3 groups. Our results showed that DLco and small airway function may already be abnormal when roentgengraphy abnormality is absent in early stage of PSS. These tests become abnormal much earlier than the reduction of lung volume in subjects who had minimal dyspnea and roentgenologic change. Our study also suggests that measurements of DLco and small airway function may be the useful diagnostic markers in early stage of pulmonary impairment of PSS before the disease is clinically serious.

关 键 词：系统性 硬化症 肺功能 诊断 结缔组织疾病 

分 类 号：R593.250.4[医药卫生—内科学]