NF—κB信号转导途径与炎症性疾病  

NF-κB signal transduction pathway and inflammatory disease

作　　者：张亚峰[1] 王骏飞[1] 蒋青[1] 

机构地区：[1]南京大学医学院附属鼓楼医院关节疾病诊治中心,210008

出　　处：《国际免疫学杂志》2007年第5期288-291,共4页International Journal of Immunology

基　　金：国家自然科学基金资助项目（30571874）

摘　　要：核因子-κB广泛存在于胞浆中，通常以p65-pso二聚体的形式存在，与抑制物IKB结合而呈非活性状态。NF-κB信号转导途径能被TNF-α、IL-1、神经生长因子等多种因素激活。激活后NF—κB信号转导途径能够调节包括生长因子、转录因子、细胞素、趋化因子、抗凋亡蛋白等在内的基因转录。NF—κB信号转导途径参与了炎症、细胞凋亡、免疫反应等病理过程。其与炎症性疾病关系密切，深入了解NF—κB信号转导途径，有助于阐明某些炎症性疾病的发病机制以及为某些炎症性疾病提供新的治疗靶点。Nuclear factor-κB （NF-κB） appears as p65-p50 heterodimers, an inactive form which binds to NF-κB inhibitor in cytoplasm. NF-κB signal transduction pathway can be activated by factors such as TNF- α, IL-1, nerve growth factor, and so on. Activated NF-κB signal transduction pathway will regulate gene expressions, for example, growth factors, transcription factors, chemotactic factors, anti-apoptosis proteases. NF-κB signal transduction pathway is involved in inflammatory disease pathogenesis, cell apoptosis, and immune response. Better understanding of NF-κB signal transduction pathway is very important to identify the mechanism of some inflammatory diseases and explore new treatment targets for these diseases.

关 键 词：NF—κB信号转导途径 炎症性疾病 

分 类 号：R3[医药卫生—基础医学]