调胃消滞丸对湿阻证模型大鼠胃液分泌及胃肠运动功能的影响  

Effect of Tiaowei Xiaozhi Pills on Gastric Juice Secretion and Gastrointestinal Function in Rats Model of Damp Stagnation Syndrome

作　　者：杨龙飞 陈丹曼 邓慧敏 苏碧茹 杨鹊[2] 

机构地区：[1]广州中一药业有限公司,广州510140 [2]广州市医药工业研究所药理研究室,广州510240

出　　处：《中药新药与临床药理》2007年第5期374-376,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的观察调胃消滞丸对湿阻证模型大鼠胃液分泌及胃肠运动功能的影响。方法复制湿阻证大鼠模型,通过胃液分泌量、胃蛋白酶等指标来考察调胃消滞丸的主要药效作用。结果调胃消滞丸高、中剂量(700,350mg/kg)能明显减少湿阻证模型大鼠胃液分泌量、降低胃液pH值、增加胃液总酸度及明显提高胃蛋白酶的活力。调胃消滞丸各剂量(700,350,175mg/kg)均能明显促进湿阻证模型大鼠的肠推进及胃排空功能。结论调胃消滞丸对湿阻证模型大鼠的胃肠功能异常有改善作用。Objective To observe the effect of Tiaowei Xiaozhi Pills on gastric juice secretion and gastrointestinal function in rats model of damp stagnation syndrome. Methods The damp stagnation syndrome model was established in rats.The gastric juice, pepsin and gastrointestinal function were determined. Results Tiaowei Xiaozhi Pills in the dosages of 700 mg/kg and 350mg/kg can diminish the amount of gastric juice and pH level and increase pepsin level. Tiaowei Xiaozhi Pills in the dosages of 700 mg/kg, 350 mg/kg, 175 mg/kg can also improve gastrointestinal function in model rats. Conclusion Tiaowei Xiaozhi Pills have improvement on gastrointestinal function in rats model of damp stagnation syndrome.

关 键 词：调胃消滞丸 湿阻证 胃蛋白酶 

分 类 号：R285.5[医药卫生—中药学]