糖尿病肾病患者尿微量蛋白与胰岛素抵抗的关系  

Relationship Between Urinary Micro-protein and Insulin Resistance in Diabetic Nephropathy

作　　者：沈娟[1] 唐艰音[1] 郁红[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院内分泌科,上海201900

出　　处：《医学临床研究》2007年第9期1470-1471,共2页Journal of Clinical Research

摘　　要：【目的】探讨2型糖尿病肾病(DN)患者尿微量蛋白(mALB)与胰岛素抵抗(IR)之间的关系。【方法】检测81例2型DN患者mALB及血糖、胰岛素、血脂等生化指标,分析各指标之间的相关性,并根据尿白蛋白量分为正常蛋白尿组与蛋白尿组进行评估。【结果】mALB与尿转铁蛋白(TRF)、尿免疫球蛋白G(IgG)、尿β2-微球蛋白(β2-MG)、尿α1-微球蛋白(α1-MG)呈正相关。蛋白尿组胰岛素敏感指数(ISI)明显低于无蛋白尿组,甘油三酯、空腹胰岛素、2h胰岛素、TRF、尿IgG、尿β2-MG、尿α1-MG均高于无蛋白尿组,且差异有显著性。【结论】mALB、TRF、尿IgG、尿β2-MG、尿α1-MG均可作为早期DN检测的指标,且与IR相关。To study the relationship between urinary micro-protein and Insulin Resistance in patients with diabetic nephropathy. [Methods]Urinary micro-protein , Blood glucose, insulin and blood lipid biochemical tests Examined were in 81 type T2DM , relationship within urinary micro-protein was analyzed, the patients with urinary Micro-albumin were classified and analyzed. [Results]Urinary transferrin（TRF）, Immunoglobulin GG（IgG）, β2-Microglobulin（β2-MG） and al-Microglobulin（al-MG） were in positive relationship with Urinary Micro-albumin（mALB）. In patients with urinary micro-protein, insulin sensitivity index（ISI） was significantly lower and triglyceride（TG）, fasting insulin（FINS）, 2h insulin（INS 2h） ,TRF, IgG,β2-MG, al-MG were all significantly higher compared with the patients without urinary micro-protein. [Conclusion]Urinary mALB,TRF,IgG, β2-MG, a1-MG are the sensitive indexes in early diagnosis of diabetic nephropathy. They are related to insulin resistance （IR）.

关 键 词：糖尿病肾病/尿 蛋白尿 胰岛素抗药性 

分 类 号：R692.39[医药卫生—泌尿科学]