幼年特发性关节炎患儿血清铁蛋白的变化及临床意义  

Clinical significance of serum ferritin in childen with system onset juveile rheumatoid arthsistis

作　　者：夏敏[1] 曹兰芳[1] 马敏[1] 

机构地区：[1]上海交通大学医学院附属仁济医院儿科,上海200001

出　　处：《中国实验诊断学》2007年第9期1162-1163,共2页Chinese Journal of Laboratory Diagnosis

摘　　要：目的观察血清铁蛋白在幼年特发性关节炎尤其是全身型患儿诊断及分型中的意义。方法采用美国Immulite铁蛋白分析仪检测全身型、多关节型、少关节型幼年特发性关节炎组以及对照组儿童血清铁蛋白,并同时抽血检测ESR、CRP。结果JIA患儿的SF明显高于对照组间SF水平有明显差异;而三型JIA患儿病例间在ESR、CRP无明显差异的情况下,SoJIA患儿SF水平明显高于其它二型患儿,有统计学意义。结论SF在JIA患儿血清中明显升高;在三型JIA患儿组ESR、CRP无差异情况下,SoJIA患者的SF明显高于其他两型。提示SF在JIA全身型的诊断中所具有的地位,应有待于进一步的重视。Objective To detemaine file evolution of levels of total serum ferritin in children with system onset Juvenile rheumatoid arthritis （SoJIA） at the time of diagnosis and typing.Methods All children with SoJIA were tested at the time of diagnosis. Total serum ferritin levels were analysed by immunoassay, and the value of ESR and CRP was determined. Results 44 clfildren with JLA were enrolled. At the time of diagnosis, total serum ferritin remained high in JIA patients and was nonnal in the others. The serum ferritin of SoJIA children was higher than the other two type JIA patients, at the same time, ESR and CRP had no difference among all JIA children. Conclusion Total sermn ferritin is a marker of the active phase of JIA and it is a marker of the active phase of SoJIA especially. Further studies are needed to confirm these data and to determine their specificity for SoJIA before considering any possible use of serum ferritin as a diagnostic tool in suspected SoJIA, especially when atypical or previously treated.

关 键 词：儿童 幼年特发性关节炎 血清铁蛋白 

分 类 号：R725.9[医药卫生—儿科]