复方参桂胶囊的质量标准研究  

Quality standard for Compound Shengui Capsules

作　　者：严楚顺 张雪静[1] 尤晓燕[1] 

机构地区：[1]上海市黄浦区中心医院,上海200002

出　　处：《中成药》2007年第9期1321-1324,共4页Chinese Traditional Patent Medicine

摘　　要：目的：建立复方参桂胶囊的质量标准。方法：采用TLC法对复方参桂胶囊中甘草、三七、丹参和川芎进行定性鉴别,采用HPLC法测定制剂中甘草酸铵和丹参酮ⅡA含量。结果：在薄层色谱中能检出甘草、三七、丹参和川芎;甘草酸铵在0.5-4μg和丹参酮ⅡA在0.04-0.32μg范围内线性良好,回归系数r分别为0.999 8和0.999 6,平均回收率分别为98.9%,97.8%。结论：建立的分析方法简便可行,专属性强,可用于复方参桂胶囊质量控制。AIM： To establish quality standard for Compound Shengui Capsules. METHODS： Glycyrrhiza uralensis Fisch. ,Panax notoginseng （Burk.） F. H. Chen, Salvia miltiorrhiza Bge. and Ligusticum chuartxiong Hort. were identified by TLC. Ammonium glycyrrhizinate and tanshinone ⅡA were determined by HPLC. RESULTS： TLC spots developed were fairly clear and the blank test showed no interference. The linear rangers were 0.5 -41μg（r =0. 999 8）for ammonium glycyrrhizinate ;0. 04 -0. 321μg（r =0. 999 6） for tanshinone ⅡA. The average recoveries of them were 98.9% ,97.8%, respectively. CONCLUSION： The methods is effective for the quality control of Compound Shengui Capsules.

关 键 词：复方参桂胶囊 TLC 甘草酸铵 丹参酮ⅡA HPLC 

分 类 号：R927.2[医药卫生—药学]