天然脑粉不对称还原制右旋龙脑  

Preparation of D-Borneol by Asymmetric Reduction of Natural Camphor Powder

作　　者：王维德[1] 黄颖芬[1] 王宁辉[1] 陈登昌[1] 

机构地区：[1]华侨大学材料科学与工程学院,福建泉州362021

出　　处：《华侨大学学报（自然科学版）》2007年第4期410-413,共4页Journal of Huaqiao University(Natural Science)

基　　金：国务院侨办科研基金资助项目(05QZR02)

摘　　要：利用樟脑还原中间产物的分子热力学稳定性的差异,在还原体系还原剂S/无水乙醇中进行樟脑的不对称还原,考察还原剂用量、溶剂用量和反应温度对反应的影响.结果表明,最佳反应条件为还原剂S与樟脑量的比为2.8,溶剂用量为15.5,反应时间为40 min,利用这种方法还原樟脑,主产物为右旋龙脑,副产物为异龙脑,两者的比例几乎固定不变.研究还表明,在该体系中还原樟脑,反应温度易于控制,反应条件比较温和,反应产物收率较高,反应所得樟脑最高转化率为78%,右旋龙脑最高产率为66%.The natural＇ camphor power is a by-product from the separation of camphor tree oil, its main component is natural D-camphor. The chemical structure of D-camphor is resemblant to D-borneol. The asymmetric reduction of Dcamphor into D-borneol, was carried out in S/ethanol＇ system by using the difference of the molecular thermodynamics stability of midway products of D-camphor reduction. The experimental results showed that a mixture with nearly fixed ratio of D-borneol and isoborneol was obtained. The conversion rate of D-camphor is 78% and the productivity rate of D-borneol is 66%.

关 键 词：天然脑粉 樟脑 右旋龙脑 不对称还原 

分 类 号：O621.34[理学—有机化学] O636.9[理学—化学]