多功能蛋白Geminin的研究进展  

Advance in The Geminin:A Multifunctional Protein

作　　者：杨宁[1] 柳惠图[1] 张伟[1] 

机构地区：[1]北京师范大学生命科学学院,细胞增殖与调控生物学教育部重点实验室,北京100875

出　　处：《生物化学与生物物理进展》2007年第9期915-924,共10页Progress In Biochemistry and Biophysics

基　　金：国家高技术研究发展计划(863)资助项目(2006AA02Z4A6);国家自然科学基金资助项目(30300173).~~

摘　　要：Geminin是一种定位于核内的多功能小分子蛋白,具有相对复杂的结构模式,在细胞增殖、胚胎发育及肿瘤发生等多方面均发挥重要作用.它通过调节细胞周期时相中的重要事件作用于细胞增殖:经多种途径参与DNA复制的调节;抑制中心体重复复制;推进G2/M期和维持正常胞质分裂等.在不同发育阶段,Geminin可作为抑制因子或是诱导因子参与胚胎发育的调节,特别是在神经形成方面.通过与同源异型盒基因或蛋白Six3及Hox等的相互作用,Geminin分别在眼睛发育及胚胎发育过程中起调节作用,并且表现出在细胞增殖与分化中协调因子的功能.近年来Geminin在肿瘤中的作用已成为研究的重点,它可作为评价肿瘤发生进程和预后的标志分子,并可望是一个新的肿瘤治疗的作用靶点.对Geminin活性的调节主要表现在转录水平和转录后水平,转录后水平的调节可能占主要地位.Geminin is a multifunctional protein which localizes in nucleus, it has complicated structural and functional domains. Geminin plays very important roles in cell proliferation, embryonic development, tumorigenesis and so on. Geminin affects cell proliferation through influence on the important events in cell cycle phases. There are many mechanisms by which Geminin can control DNA replication, inhibit centrosome over-duplication, promote G2/M phase progression, maintain proper cytokinesis. At different development stages, Geminin acts as an inhibitor or inducer in regulating embryonic development, especially in nervous system formation. Geminin also plays a regulative role in eye development and embryonic development through the interactions with homeobox genes or proteins Six3 and Hox, Geminin functions as a coordinator of cell proliferative and differentiative control. Recently, Geminin was found to have relationship with cancer, the study on the function of Geminin in cancer has been a meaningful aspect. Geminin can act as a marker to evaluate progression and prognosis in cancer. It may be a novel molecular target in therapy of cancer. The activity of Geminin is regulated by transcription level and post-transcription level, the post-transcriptional regulation of Geminin protein may take the main position.

关 键 词：GEMININ 细胞增殖 胚胎发育 肿瘤 

分 类 号：Q291[生物学—细胞生物学]