可循环利用的固体氧化剂两相氧化偶联合成2-氨基-2'-羟基-1,1'-联萘的研究  

Study on Synthesis of 2-Amino-2'-hydroxy-1,1'-binaphthyl by Two-phase Oxidative Coupling with a Cyclic Solid Oxidant

作　　者：蒋毅[1] 王娟芸[1] 陈君和[1] 王伟军[1] 闫寒[1] 张小霞[1] 王超[1] 张国林[2] 李伯刚[2] 

机构地区：[1]中国科学院成都有机化学研究所,成都610041 [2]中国科学院成都生物研究所,成都610041

出　　处：《化学学报》2007年第17期1925-1928,共4页Acta Chimica Sinica

摘　　要：采用浸渍法制备了不同负载量的FeCl3/Al2O3固体氧化剂,并考察了载体和溶剂对氧化2-萘胺和2-萘酚交叉偶联的影响.结果表明:在60℃,氯苯作溶剂的情况下,含TiO2(质量分数)5%的载体,负载10%FeCl3时2-氨基-2'-羟基-1,1'-联萘(NOBIN)的收率最高达到了95.01%;用过的固体氧化剂经H2O2氧化处理后活性明显恢复,证明此法是一条循环再生的有效途径.Various solid-oxidants with different loadings of FeCl3 on A1203 were prepared by impregnation. The effects of support and solvent on the oxidative cross-coupling of 2-naphthol with 2-naphthylamine using FeCla/A12O3 were studied. Up to 95.01% yield of 2-amino-2＇-hydroxy-l,l＇-binaphthyl （NOBIN） was obtained in chlorobenzene using the oxidant with 10% FeC13 loading on the support containing 5% TiO2 at 60 ℃. The activity of the used oxidant was improved by treatment with H2O2, which provided an effective method to regenerate the solid-oxidant.

关 键 词：2-萘胺 2-萘酚 固体氧化剂 交叉偶联 2-氨基-2'-羟基-1 1'-联萘 

分 类 号：O625.6[理学—有机化学]