骨科医院麻醉科用药及药物不良反应监测  

Anesthetic Drug Use and Monitoring of Adverse Drug Reactions in An Orthopedic Hospital

作　　者：燕兴梅[1] 杨毓章[2] 高桂英[1] 肖跃平[2] 张国顺[1] 崔永武[1] 武利栓[1] 

机构地区：[1]内蒙古医学院第二附属医院麻醉科,010030 [2]内蒙古医学院药理教研室,010059

出　　处：《药物流行病学杂志》1997年第1期13-16,共4页Chinese Journal of Pharmacoepidemiology

基　　金：国家自然科学基金资助

摘　　要：对105例骨科手术麻醉患者的麻醉用药,药物不良反应(ADRs)及其他不良情况(AEs)进行系统监测。105例出现ADRs者18例,29例次,ADRs发生率17.1％;出现AEs者28例,29例次,AEs发生率26.7％。18例ADRs者中以利多卡因最多(10例),布比卡因其次。ADRs表现顺序为恶心呕吐(8例次),血压降低,头晕等。AEs原因中输液反应最多,表现寒战发热多见。全部麻醉用药共20种,使用频率顺序为利多卡因(81.9％),氟芬合剂(45.7％),布比卡因(39.0％),安定(32.4％),地塞米松(23.8％),氯胺酮(6.7％)等。麻醉药使用频率单用利多卡因最多(50.5％),其次为利多卡因与布比卡因联用(25.7％)。氟芬合剂广泛辅助使用于6种麻醉方法中。本文ADRs发生率较低,认为原因是选药合理,用量适当,合理配伍及适当使用辅助药。The use of anesthetic drugs, adverse drug reactions (ADRs) and other adverse events (AEs) were systematically monitored in 105 patients subjected to anesthesia during orthopedic operation. 18 patients developed ADRs (26 times) with incidence being 17.1%. 29 time AEs was found in 28 patients with an AE incidence of 26.7% . Lidocaine had the highest frequency of use (10/18, 55. 6% ) , followed by bupivacaine. The ADRs included vomiting and nausea, blood pressure drop and dizziness etc. in order of occurrence. Fluid infusion reaction was the commonest of AEs, manifested by shivering and fever. There were 20 kinds of anesthetics and they included, in order of use frequency, lidocaine (81.9%), innovar (45.7%), bupivacaine (39.0%), valium (32.4%), desamethason (23.8%) and ketamine (6.7%) etc. . The single use of lidocaine (50.5%) had the highest use frequency, followed by combined use of lidocaine and bupivacaine (25.7%). Innovar was extensively used as an adjuvant drug in the existing 6 anesthesia techniques. In our series, the ADR incidence was low. This may be due to the correct selection of drugs, suitable dosage, reasonable combination of narcotherapy and use of adjuvant drugs.

关 键 词：麻醉用药 麻醉剂 骨科手术 药物不良反应 

分 类 号：R614[医药卫生—麻醉学] R971.2[医药卫生—外科学]