猴自身给药方法评价盐酸二氢埃托啡的精神依赖性潜力  

PSYCHOLOGICAL DEPENDENCE POTENTIAL OF DIHYDROETORPHINE IN RHESUS MONKEYS

作　　者：王卫平[1] 王桂林 哈鹰[1] 郑继旺[1] 

机构地区：[1]北京医科大学中国药物依赖性研究所,北京100083

出　　处：《中国药物依赖性通报》1997年第1期8-12,共5页

摘　　要：本实验采用4个实验对盐酸二氢埃托啡(DHE)的精神依赖性潜力进行了较系统的评价 ,并与其他阿片类药物进行了比较。在FR1程序下 ,未接触过药物的恒河猴可学会踏板觅药并维持对DHE的自身给药行为 ,潜伏期较短。在交叉替代实验中 ,DHE与其他阿片类药物有良好的交叉耐受性。在可变比率实验中 ,最高的稳定比率值为VR100。在累进比率实验中 ,断点达到2022 ,而海洛因只有911。结果证明 ,盐酸二氢埃托啡具有很强的精神依赖性潜力 ,其精神依赖性潜力比海洛因强得多 ,且具有成瘾潜伏期较短 ,相邻两次注射间隔短等特点。虽然镇痛作用较强 ,但作为临床用药仍有很大的危险性。This study was undertaken to systematic assess psychic dependence potential research of dihydroetorphine (DHE) by 4 experiments in rhesus monkeys, and compared with other opiate. Under FR1 and 6 hours session to access to DHE at training dose 0.25 μg·kg-1, the previous naive monkeys could learn to press lever and maintain intravenous self-administration (SA) spontaneously, but incubation period was shorter. In cross substitution SA, DHE could be good maintained on a stable TDD after substitution with other opiates respectively. In VR schedule, the highest ratio was VR100, TDD has not change. In PR schedule, the stable breakpoint of DHE was 2022, but that of heroine was only 911. Result has been proved, DHE has showed high psychological dependence potential and strong reinforcing effects.

关 键 词：盐酸二氢埃托啡 自身给药方法 精神依赖性潜力 

分 类 号：R971.1[医药卫生—药品]