缺铁患者血清白细胞介素-1β水平测定  

Evaluation of serum interleukin-1β concentration in patients with iron deficiency

作　　者：王景文[1] 张之南[1] 李蓉生[1] 杨江燕[1] 李琦[1] 

机构地区：[1]北京协和医院血液科

出　　处：《中国病理生理杂志》1997年第2期188-191,共4页Chinese Journal of Pathophysiology

摘　　要：用双抗体夹心酶联免疫吸附试验检测13例缺铁(ID)患者血清白细胞介素-1(SIL-1β)水平,结果显示:缺铁患者SIL-1β水平明显高于正常对照组,且和ID程度呈正相关。SIL-1β水平增高可能是ID的一种代偿性反应,其实际意义值得进一步探讨。Serum interleukin-1/3(SIL-1/3) concentration was determined in 13 women with iron deficiency (ID). SIL-1β concentration(estimated by ELISA) was very much higher in ID group than healthy controls (P<0.001). After 4 weeks of oral iron therapy, SIL-1β concentration in the ID group decreased significantly as compared with that before the treatment (P<0.02), but yet did not drop to normal level. A very significant positive correlation was found between SIL-1β concentration and free erythrocyte protoporphyrin (r=0.52, P<0.01) in the ID group and the control group. A very high negative correlation was also found between SIL-1β concentration and serum ferritin (r=-0.46, P<0.01), and so was between SIL-1β concentration and erythrocyte fcrritin(r=-0.64, P<0.01) in ID group and control group. The increased S1L-1β concentration in 1D probably reflects a secondary or compensatory reaction and its clinical significance remains to be further delined.

关 键 词：缺铁 血清 白细胞介素1 

分 类 号：R591.103[医药卫生—内科学]