以精氨酸负荷试验观察原发性高血压胰岛内分泌功能的变化  

Observation of Effects of Arginine Loading Test on Pancreas Islet Function in Hypertensives

作　　者：张敏[1] 王珍[2] 于宏伟[1] 杨立廷[1] 綦玉芹[1] 

机构地区：[1]青岛医学院附属医院内分泌科,266003 [2]青岛医学院附属医院干部保健科,266003

出　　处：《天津医药》1997年第4期195-197,共3页Tianjin Medical Journal

摘　　要：对51例原发性高血压(EH)患者和30例对照组进行精氨酸负荷试验,测定负荷前、后血糖、胰岛素、c肽、胰高糖素水平。结果显示,EH患者精氨酸负荷前、后胰岛素和胰高糖素均高于对照组(P<0.05或更小)。负荷前C肽高于对照组(P<0.05),负荷后与对照组无显著差异。EH患者胰岛素敏感性指数低于对照组(P<0.001),提示精氨酸负荷后胰岛素升高是清除率下降所致。EH的胰岛素敏感性下降可能与胰高糖素升高有关,胰高糖素升高可能对EH患者发生糖尿病有促进作用。The blood levels of glucose,insulin,C-peptide and glucagon in fifty-one patients with essential hypertension and thirty controls were measured before and after intravenous arginine loading. The results showed that essential hypertension patients had higher levels of insulin and glucagon (P< 0.05 or less)before and after intravenous arginine,higher C-peptide level (P<0. 05) before intravenous arginine, and no difference after intravenous arginine than the controls. Insulin sensitive index was lower (P<0. 001)in hypertensives than controls. The findings suggested that hyperinsu-linemia resulted from decreased insulin clearance, the reduction of insulin sensitivity might be related to raised glucagon. The hyperglucagonemia might be contributed to development of diabetes mellitus in hypertensive patients.

关 键 词：高血压 精氨酸 胰高糖素 胰岛素 负荷试验 

分 类 号：R544.102[医药卫生—心血管疾病]