葛根素、生石膏配伍对致热原作用下猫POAH温敏神经元放电的影响  

EFFECTS OF BOTH PUERARIN AND GYPSUM ON THE FIRING OF PYROGEN TREATED THERMOSENSITIVE NEURONS IN THE REGION POAH OF ANESTHETIZED CATS

作　　者：范书铎[1] 孙丽华[1] 吴玉环[1] 赵红艳[1] 

机构地区：[1]中国医科大学生理教研室

出　　处：《中国应用生理学杂志》1997年第1期71-74,共4页Chinese Journal of Applied Physiology

基　　金：国家自然科学基金

摘　　要：应用微电极细胞外记录技术，在３４只猫ＰＯＡＨ区记录了温敏神经元单位放电，研究中药葛根素和生石膏解热可能的中枢机制。致热原使１４例热敏神经元放电频率减少；使１１例冷敏神经元放电频率增加。注射等量葛根素和生石膏能反转上述作用。致热原及二药对５例温度不敏感神经元放电无影响。结果显示，葛根素和生石膏是影响致热原作用下ＰＯＡＨ区温敏神经元的电活动而解热的。二者配伍使用对冷敏神经元放电频率的影响比单独使用作用强，提示在中枢水平二者有协同作用。To investigate the possible central mechanism of antipyretic effects of Chinese medicines,puerarin and gypsum,the firing rate of thermosensitive neurons in preoptic anterior hypothalamus (POAH) region of 34 cats was recorded by using extracellular micro electrode technigue. Injection of pyrogen caused decrease in firing rate of 14 warm sensitive neurons and increase in firing rate of 11 cold sensitive neurons in the region of POAH.The effects could be reversed by the injection of puerarin and gypsum. The results showed the antipyretic action of puerarin and gypsum might be mediated by influences on the electroactivity of pyrogen treated thermosensitive neurons in the region of POAH. Effect of puerarin and gypsum on cold sensitive neurons was stronger than that of single one, suggesting that both are synergic in central level.

关 键 词：中药葛根素 生石膏 POAH 温度敏感神经元 药理学 

分 类 号：R285.5[医药卫生—中药学]