IA-2Ab、GAD-Ab、IAA对1型和2型糖尿病的鉴别价值  

The diagnostic values of IA-2Ab,GAD-Ab AND IAA in distinguishing between type 1 and 2 diabetes mellitus

作　　者：吴东红[1] 刘岳鸿[1] 柳杰[1] 徐滨华[1] 苏雁[1] 窦春霞[1] 陈洪波[1] 

机构地区：[1]哈尔滨市第一医院内分泌科,150010

出　　处：《中国糖尿病杂志》2007年第9期522-523,共2页Chinese Journal of Diabetes

摘　　要：对46例1型糖尿病(T1DM)患者、48例2型糖尿病(T2DM)患者,50例T1DM患者非糖尿病一级亲属(N-DMFR)及46例健康志愿者(NC)的酪氨酸磷羧酶抗体(IA-2Ab)、谷氨酸脱羧酶抗体(GAD-Ab)和胰岛素自身抗体(IAA)以及FPG、2hPG、HbA1c、胰岛素、C肽。结果IA-2Ab阳性者T1DM组为47.8%、N-DMFR组为28%,明显高于NC组(P<0.05);GAD-Ab阳性者T1DM组71.7%、N-DMFR组24%,明显高于NC组(P<0.05);IAA阳性者为T1DM组65.2%、T2DM组8.3%、N-DMFR组4.0%、NC组无阳性者。两种或两种以上抗体阳性者T1DM组63.0%,N-DMFR组6%;T2DM及NC组无检出者。IA-2Ab、GAD-Ab、IAA的联合检出有利于糖尿病的预测、早期诊断及正确分型。IA-2Ab,GAD-Ab,IAA,FPG, 2h PG, HbA1c,serum insulin （INS） and C-peptide （CP） were measured in 46 type 1 diabetics （group A） ,48 type 2 diabetics （group B） ,50 non-diabetic first-degree relatives（N-DMFR） of type 1 diabetics （group C） and 46 normal individuals （group D）. The positive rates of IA-2Ab in group A,B,C and D were 47.8% ,6.3% ,28% and 2.4% respectively. The positive rates of GAD-Ab in group A,B,C and D were 71.7% ,4.2% ,24% and 2.4% respectively. The positive rates of IAA in group A,B,C and D were 65.2% ,8.3% ,4.0% and 0%. The positive rates of two or more antibod- ies in group A and C were 63% ,6% respectively and negative in group B and C. The combined determination of IA-2Ab,GAD-Ab and IAA is essential for distinguishing between type 1 and 2 diabetes.

关 键 词：酪氨酸磷酸酶抗体 谷氨酸脱羧酶抗体 胰岛素自身抗体 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]