Resistin与急性冠脉综合征、稳定性心绞痛相关性研究  

Study on the Relationship between Serum Resistin and Acute Coronary Syndrome and Stable Angina Pectoris

作　　者：乔小芝[1] 杨云梅[1] 徐哲荣[1] 杨丽爱[1] 吴灵娇[1] 

机构地区：[1]浙江大学医学院附属第一医院,浙江杭州310003

出　　处：《浙江预防医学》2007年第9期14-15,19,共3页Zhejiang Journal of Preventive Medicine

基　　金：浙江省科技厅项目2003C33031

摘　　要：目的探讨急性冠脉综合征(Acute coronary syndrome,ACS)[急性心肌心梗(Acute MyocardialInfarction,AMl)、不稳定性心绞痛(Unstable Angina Pectoris,UAP)]、稳定性心绞痛(Stable Angina Pectoris,AP)患者血清Resistin水平的变化及可能的临床意义。方法ELISA法测定24例AMI、19例UAP、22例AP患者和26例健康对照者血清Resistin蛋白水平。用常规实验方法测定血白细胞总数(WBC)、超敏C反应蛋白(hsCRP)、心肌肌酸激酶(CK)、心肌肌酸激酶同工酶(CK-MB)、肌钙蛋白(cTnl)。结果AMI组血清Resistin蛋白水平[(8.16±5.16ng/m1],UAP组[(5.59±2.71]ng/m1,AP组[(3.45±1,52)ng/m1],均明显高于对照组[(1.63±0,96)ng/ml],P<0.05;AMI组高于UAP、AP组,P<0.05;UAP组高于AP组,P<0.05。血清Resistin蛋白水平与WBC(r=0.412,P=0.046)、hsCRP(r=0.427,P=0.037)和CKmax、CK-MBmax、cTnlmax正相关(相关系数分别为0.731、0.678、0.656,P<0.01)。结论血清Resistin蛋白与心肌损害大小及炎症标志物有关,随着病情的进展、心肌损害的加重,血清Resistin水平呈增高趋势,提示血清Resistin蛋白可能作为炎症因子参与动脉粥样硬化和急性心肌梗死的发生、发展。Objective To investigate serum Resistin levels in patients with acute coronary syndrome （ACS） [acute myocardial infarction （AMI）, unstable angina pectoris （UAP） ] and stable angina pectoris （AP）. Methods 24 patients with AMI, 19 patients with UAP, 22 patients with AP and 26 healthy individuals were randomly selected, The method of ELISA was used to determine the serum Resistin level. Routine biochemical methods were couducted to measure WBC, hsCRP, CK, CKMB and cTrd. Results Serum Resistin levels of AMI, UAP and AP groups were higher than that of control group （p 〈 0.05）. Serum Resistin level of AMI group was higher than that of UAP and AP groups （p 〈 0.05）. Serum Resistin level of UAP group was higher than that of AP group （p 〈 0.05）. Serum Resistin positively correlated with WBC （r = 0.412, p 〈 0.05）, hsCRP （r= 0.427, p 〈 0.05）, CKmax （r= 0.731, p 〈 0.01）, CK-MBmax （r= 0.678, p 〈 0.01 ） and cTnImax （r =0.656, p 〈 0.01）, respectively. Conclusions Serum Resistin level is closely related to inflammatory factor level and myocardial impairment. Serum Resistin may play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.

关 键 词：RESISTIN 急性冠脉综合征 稳定性心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]