布鲁菌免疫分子研究进展  

Advance in the Immune Molecules of Brucella

作　　者：吴朔[1] 赵忠鹏[1] 于三科[2] 王希良[1] 

机构地区：[1]军事医学科学院微生物流行病研究所免疫室病原微生物生物安全国家重点实验室,北京100071 [2]西北农林科技大学动物医学学院,陕西杨陵712100

出　　处：《动物医学进展》2007年第9期65-69,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金资助(30170853)

摘　　要：布鲁菌病是布鲁菌引起的人兽共患传染病,包括7种21型,其中感染人的主要有牛、羊、猪布鲁菌3种,其免疫涉及体液免疫和细胞免疫。在布鲁菌的免疫过程中,先天性免疫应答主要通过补体、自然杀伤细胞、巨噬细胞、细胞因子等的参与。获得性免疫应答中,CD4+、CD8+、γβT细胞起重要作用。布鲁菌重组亚单位疫苗是近年研究的热点,而且发现的免疫分子也很多。文章围绕布鲁菌免疫机理、免疫相关分子进行探讨,为筛选疫苗候选分子奠定基础。Brucellosis is one of the bacterial zoonosis in the world caused by the genus Brucella, and it consists of 7 nomenspecies and 21 biotypes, human being can infect by B. Bortus .B. melitensis .B. suis. Humoral and cellular immune response are involved in protect the host from the disease. In the stage of infection of brucella, innate immune responses is mediated by complement. NK cells.macrophages and cytokine; CD4^＋ ,CD8^＋ .γβT cells are very important in the adaptive immune responses. At present the subunits vaccine is studied widely and many immune molecules are founded. In this review we focus on discussing the immunity mechanism and some of the molecules of immunome to Brucella, so it can lay a foundation for brucella to screen vaccine candidates.

关 键 词：布鲁菌 免疫组 免疫分子 

分 类 号：S852.614[农业科学—基础兽医学]