马沙拉嗪的合成工艺改进  

Improved Process of the Synthesis of Mesalazine

作　　者：周晶[1] 王效山[1] 何黎琴[1] 黄鹏[1] 孙志华[1] 周娟[1] 

机构地区：[1]安徽中医学院药学院,安徽合肥230038

出　　处：《安徽化工》2007年第4期19-20,共2页Anhui Chemical Industry

摘　　要：苯胺重氮化生成重氮盐,和水杨酸偶合形成偶氮化合物,再还原得到马沙拉嗪。得到总收率为80%的马沙拉嗪,产品达到药用标准。该方法简单,原料易得,后处理简单,适合工业化生产。Improved process of the synthesis of mesalazine was introduced in this paper. The process of technology included diazotization, diazo coupling reaction and reduction. The total yield was 80%. Methods is simple, raw material is so easy, the post-processing is simple, industrialization is suitable to produces.

关 键 词：马沙拉嗪 合成 偶氮还原法 

分 类 号：R914.5[医药卫生—药物化学]