改水对林州市食管癌发病率、死亡率影响的纵横对比研究  

Historical cohort study of Effect of drinking water improvement on mortality of esophageal carcinoma among Linzhou residents

作　　者：韩建英[1] 徐致祥[2] 邢海平[1] 谭家驹[2] 王民宪[1] 张栓虎[1] 孔芳君[1] 司建华[2] 李笑梅[1] 唐丽娜[2] 田谱琴[1] 

机构地区：[1]安阳市疾病预防控制中心,河南安阳455000 [2]佛山市第一人民医院,广东佛山528000

出　　处：《河南预防医学杂志》2007年第5期321-325,共5页Henan Journal of Preventive Medicine

基　　金：安阳市科技局社发公关项目:安财(2005)16;安科(2005)26

摘　　要：目的探讨林州市食管癌发病率、死亡率与实验改水的关系。方法根据蚕豆根尖细胞微核实验,把林州市不同类型水按污染程度分为实验改水组、非实验改水组,对两组食管癌发病率、死亡率分别进行横向和纵向对比,同时,将饮用水污染指数最高乡和最低乡,分别进行发病率、死亡率横向和纵向对比,使用χ2检验,进行统计学处理。结果实验改水组发病率、死亡率显著低于非实验改水组,实验改水组改水前后纵向比较发病率、死亡率分别下降29.00%、43.32%,下降具有显著的统计学意义,非实验改水组改水前后纵向比较下降不显著。饮用水未被污染,微核污染指数<1.5的乡,其发病率、死亡率最低,与改水前纵向比较,发病率、死亡率分别下降44.70%、57.74%,均有显著的统计学意义;饮用水重度污染组发病率、死亡率最高,与改水前纵向比较,发病率、死亡率没有显著改变。结论改水显著降低食管癌发病率、死亡率,改水、消除污染源、保护水源是预防食管癌的关键措施。Obiective To observe the influenceof of drinking water improvement on mortality of esophageal carcinoma among Linzhou residents. In order to test the hypothesis of ＂nitrogenous compound metabolised cycling＂ in etiology of EC. Methods Historical cohort study of different kinds of water on morbidity and mortality of ofesophageal cancer（ EC） in Linzhou residents. Based on the investigating data collected in 1959 - 2003 among which data were from Linzhou Institute of Prevention and Treatment of EC. Two kinds of water were included. Standardized deep well Water（ SDWW） from the well with the depth exceeding 100 meters ,finished time exceeding 6years, polluted index 〈 1.5. that micronucleus effects on the root tips of vicia faba induced by different kinds of drinking water. unstandardized deep well Water（ UDWW）. The morbidity and mortality of （ EC ） in the related population. Results： According to the registered data of EC in linzhou County during 1959a - 2003a. There were 867126 residents. 210973 residents to drink SDWW, 656153 residents to drink UDWW during 2003a. The morbidity and mortality of EC had significantly decreased 59.78% and 72.97% in residents drinking of the SDWW during 2001 - 2003a compared with the highest during 1971 - 1973a. It were reduced 44.50% - 57.56% during 2001 -2003a compared with 1971 -1987 年 with historical cohort study of 210973 residents to drink SDWW. Conclusion Afire water supply changed,the drinking water quality turned better, the morbidity and mortality of EC in Linzhou residents have showed adecreasing trend.

关 键 词：实验改水 食管癌 队列研究 

分 类 号：R123.5[医药卫生—环境卫生学] R735.1[医药卫生—公共卫生与预防医学]