高血压及高胆固醇血症对颅内外动脉粥样硬化形成的实验研究  

Experimental study of atherosclerotic formation induced by hypertension and hypercholesterolemia in intra-/extracranial arteries

作　　者：张天林[1] 杨露春[1] 安同岭[1] 

机构地区：[1]天津医科大学总医院神经内科,天津300052

出　　处：《天津医科大学学报》2007年第3期360-362,372,共4页Journal of Tianjin Medical University

摘　　要：目的:探讨高血压和高胆固醇血症独立和协同作用对颅内、外动脉粥样硬化形成的影响。方法:以雄性家兔为实验对象,分成4组:正常对照组(N组,4只)、单纯高血压组(HT组,4只)、单纯高胆固醇血症组(CH组,10只)和高血压加高胆固醇血症组(HT+CH组,13只)。每日饲喂胆固醇建立高胆固醇血症模型。用双肾动脉狭窄法制成肾性高血压模型。实验结束后,所有兔主动脉、颈动脉和脑标本全部HE染色,部分标本Masson、PTH和苏丹IV染色。每组均有部分脑动脉标本做电镜检查。结果:N组和HT组颅内、外动脉未见动脉粥样硬化病变。CH组主动脉和颈动脉可见动脉粥样硬化病变,但颅内动脉未见动脉粥样硬化病变。HT+CH组主动脉和颈动脉动脉粥样硬化病变明显,且该组3只兔颅内脑实质外较大动脉出现动脉粥样硬化病变。结论:高血压和高胆固醇血症共同作用可造成颅内、外较大动脉发生动脉粥样硬化;单纯高胆固醇血症易于造成主动脉和颈动脉明显粥样硬化病变。Objective： To study the effect of hypertension and hypercholesterolemia,independently or cooperatively, on atherosclerotic formation in intra-/extracranial arteries. Methods： The domestic male rabbits were used as the experimental animals which were divided into four groups： control group （N group, 4 rabbits）, hypertension group （HT group, 4 rabbits）, hypercholesterolemia group （CH group, 10 rabbits） and hypertension plus hypercholesterolemia group （HT＋CH group, 13 rabbits）. Hypercholesterolemia was made with feeding 1 gram pure cholesterol per rabbit every day. The renal hypertension was created with clipping the bilateral renal arteries. All aortas, carotid arteries and brains were stained with HE. The some of them were stained with Masson, PTH and Sudan. Some cerebral artery samples of each group were studied with electron microscope. Results： No atherosclerosis was seen in the intra-/extracranial arteries in the N group and the HT group. Atherosclerosis in the aortas and carotid arteries were evident in CH group, but the same lesions were not seen in the intracranial arteries. In the HT＋CH group atherosclerotic lesions were obvious in the aortas and carotid arteries. Atherosclerosis also appeared in the large arteries in the cranium in 3 out of 13 rabbits in the HT＋CH group. Conclusion： Atherosclerosis in the large arteries of the intra-/extracranium can be induced by both hypertension and hypercholesterolemia cooperatively. Pure hypercholesterolemia can lead to atherosclerotic formation in the aortas and carotid arteries.

关 键 词：动脉粥样硬化 高血压 高胆固醇血症 缺血性脑卒中 兔 

分 类 号：R332[医药卫生—人体生理学] R743.1[医药卫生—基础医学]