高血压前期动脉弹性与胰岛素抵抗的相关性研究  

Correlation between Arterial Compliance and Insulin Resistance in Prehypertensive People

作　　者：王英杰[1] 胡婉英[1] 

机构地区：[1]上海中医药大学附属曙光医院(东院)心内科,上海市201203

出　　处：《中国康复理论与实践》2007年第9期872-873,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的探讨高血压前期大动脉、小动脉弹性与胰岛素抵抗的相关关系。方法选择高血压前期36人、1-2级高血压患者46例、理想血压健康者30人,使用CVProfilorDO-2020动脉弹性功能测定仪检测桡动脉脉搏波形和动脉弹性指数C1和C2,采用HOMA-IR公式计算胰岛素抵抗指数(IR);比较各组间大动脉、小动脉弹性情况,对高血压前期者动脉弹性与IR进行相关分析。结果校正了年龄和病程后,高血压组与理想血压组、高血压前期组比较,C1和C2均降低(P<0.05);高血压前期组与理想血压组比较,C2降低(P<0.05),高血压前期组和高血压组与理想血压组比较,HOMA-IR升高(P<0.05)。C2与HOMA-IR负相关(r=-0.687,P<0.05)。结论高血压前期者已经存在小动脉弹性的减退及胰岛素抵抗,且两者之间呈负相关。Objective To investigate the correlation between the arterial compliance and insulin resistance in the prehypertensive people.Methods 30 healthy persons,36 prehypertensive persons and 46 hypertensive patients were measured Cl and C2 using CVProfilor DO-2020 and determined insulin sensitivity with HOMA-IR.Results Adjusted for the age and the course of disease,C1 and C2 decreased in hypertensive patients compared with that of the healthy and prehypertensive people（P〈0.05）;C2 decreased in prehypertensive people compared with the healthy groups（P〈0.05）.HOMA-IR increased in hypertensive patients and prehypertensive people compared with the healthy groups（P〈0.05）.There was significant correlation between HOMA-IR and C2 in prehypertensive people.Conclusion Small arterial compliance decrease and insulin resistance can be found with negatively correlation in prehypertensive people.

关 键 词：高血压前期 高血压 动脉弹性 胰岛素抵抗 

分 类 号：R544.1[医药卫生—心血管疾病]