中医分型治疗慢性再生障碍性贫血临床研究  

The Clinical Study of Chinese Medicine Typing to Treating Chronic Aplastic Anemia

作　　者：石琳[1] 

机构地区：[1]河南省中医院,河南郑州450002

出　　处：《河南中医学院学报》2007年第5期41-42,共2页Journal of Henan University of Chinese Medicine

摘　　要：目的:探讨再造生血颗粒治疗慢性再生障碍性贫血(CAA)肾阴虚型和肾阳虚型患者的临床疗效和作用机理。方法:选取慢性再障患者40例,其中肾阴虚型22例,肾阳虚型18例。均口服再造生血颗粒0.5 a。检测治疗前后骨髓CD34+细胞bcl-2、bax蛋白的表达。结果:治疗后肾阳虚型基本治愈9例,缓解6例,明显进步2例,无效1例,有效率为90.9%。肾阳虚型分别为5例、5例、8例、4例,有效率为81.8%。两组比较,P<0.05。肾阳虚型患者的疗效明显优于肾阴虚型者。结论:肾阳虚型治疗前bcl-2值明显高于肾阴虚型,bax则相反。Objective： to approach the clinical effect and mechanism of reconstruction hemogenesis granules on treating chronic aplastic anemia of deficiency of kidney-yin and deficiency of kidney-yang. Method： 40 cases with chronic aplastic anemia （deficiency of kidney-yin is 22 cases and deficiency of kidney-yang is 18 cases） were treated with reconstruction hemogenesis granules on 6 months. marrow CD34 ＋ cell bcl - 2 and bax express were detected before and after treatment. Result： elementary curing is 9 cases, anesis is 6 cases, obviously improvement is 2 cases and ineffective is 1 case in deficiency of kidney-yang. The effective power is 90.9% ; elementary curing is 5 cases, anesis is 5 cases, obviously improvement is 8cases and ineffective is 4 cases in deficiency of kidney-yin. The effective power is 81.8%. the curative effect is better in deficiency of kidney-yang than deficiency of kidney-yin. Conclusion： bcl- 2 value is higher in deficiency of kidney-yang than deficiency of kidney-yin before treatment and bax is opposite.

关 键 词：再造生血颗粒 慢性再障 肾阴虚型 肾阳虚型 骨髓CD34+细胞 bcl-2 bax 

分 类 号：R259.565[医药卫生—中西医结合]