胰岛素样生长因子-I与2型糖尿病患者骨密度关系的研究  

Relationship between Bone Mineral Density and Serum Insulin-Like Growth Factor-1 in Patients with Type 2 Diabetes Mellitus

作　　者：孙明谨[1] 李雪锋[1] 陈世清[1] 胡清[1] 王芳[1] 曾玉琴[1] 

机构地区：[1]郧阳医学院附属太和医院内分泌科,湖北十堰442000

出　　处：《中国误诊学杂志》2007年第23期5456-5458,共3页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨胰岛素样生长因子-I(IGF-I)在2型糖尿病患者骨质疏松(OP)发病中的作用与机制。方法:用双能x线骨密度仪分别测定2型糖尿病患者骨密度值(BMD);用酶联免疫的方法测定受试者血清IGF-I的水平,并与正常对照组比较。结果:2型糖尿病组骨密度低于对照组(P<0.01);血清IGF-I水平低于对照组(P<0.01);糖尿病患者骨密度值与血清IGF-I水平显著正相关(P<0.01)。结论:2型糖尿病组OP发病率增高,与IGF-I水平降低导致骨形成减少有关。Objective：To explore the role of insulin-like growth factor-I（IGF-I） in onset of osteoporosis in patients with type 2 diabetes mellitus.Methods：BMD was measured by double-X ray bone mineral density meter.The level of serum IGF-I was detected by enzyme linked immunosorbant assay.Results：Compared with normal control group,the bone mineral density in type 2 diabetes was significantly lower（P〈0.01）,and the level of serum IGF-I was significantly lower（P〈0.01）.In type 2 diabetes mellitus group,the BMD was positively related with IGF-I （P〈0.01）.Conclusions：The morbidity of osteoporosis in type 2 diabetes mellitus is higher.IGF-I plays a critical role in the pathogenesis of bone formation.

关 键 词：糖尿病 2型/血液 胰岛素样生长因子/代谢 骨密度/生理学 骨质疏松/病理生理学 人类 

分 类 号：R587.1[医药卫生—内分泌]