银杏黄酮磷脂复合物自乳化释药系统处方研究  

Study on Optimizing the Formula of Lecithin Compound Ginkgo Flavone Glycosides Self-emulsifying Drug Delivery System

作　　者：耿旦[1] 

机构地区：[1]广西钦州市第一人民医院药剂科,广西钦州535000

出　　处：《药学进展》2007年第9期419-423,共5页Progress in Pharmaceutical Sciences

摘　　要：目的:优化银杏黄酮磷脂复合物自乳化释药系统处方。方法:以银杏黄酮磷脂复合物在不同种类及比例的油相、表面活性剂中的溶解度为考察指标,筛选自乳化释药系统处方。结果:该处方制备的银杏黄酮磷脂复合物自乳化软胶囊能够迅速溶解并乳化,在蒸馏水、pH6.8磷酸缓冲液和0.1mol/L的HCl中,该系统中的银杏黄酮在45分钟内的溶出度均在80%以上。结论:该自乳化释药系统大大提高了银杏黄酮在水中的溶出度。Objective： To optimize the formula of lecithin compound Ginkgo Flavone Glycosides self-emulsifying drug delivery system. Methods： Screening the formula of lecithin compound Ginkgo Flavone Glycosides serf-emulsifying drug delivery system based on the compound solubility in various kinds and ratios of surfactants and oil phases. Results： The optimized serf-emulsifying soft capsule was quickly dissolved and emulsified. The dissolution of it was over 80% at 45 min in distilled water, pH 6.8 phosphate buffer and 0.1 mol/L HCl. Conclusion： The dissolution of Ginkgo Flavone Glycosides in water is significantly increased by using optimized formula of self-emulsifying drug delivery system.

关 键 词：银杏黄酮 自乳化软胶囊 溶出度 

分 类 号：R94[医药卫生—药剂学]