抗结核植物疫苗的研究进展  

Study Development of Anti-tuberculosis Plant Vaccine

作　　者：陈立志[1] 张秀华[1] 叶庆明[1] 刘晓颖[1] 

机构地区：[1]中国农业科学院特产研究所,吉林吉林132109

出　　处：《特产研究》2007年第3期57-60,共4页Special Wild Economic Animal and Plant Research

基　　金：吉林市科技发展计划项目(200615-3)

摘　　要：结核病是由结核分支杆菌引起的一种人畜共患慢性传染病,对动物和人危害极大。卡介苗(BCG)是当前预防结核病的唯一商品化疫苗,在其应用的50余年取得了一定的防治效果,但总体的有效防治率只有50%。结核杆菌分泌蛋白作为亚单位疫苗,具有良好的免疫原性,可以诱发机体产生抗结核的免疫保护。而植物疫苗作为一种新型疫苗,和其它疫苗相比具有廉价、无副作用、可大规模生产等优点。转基因植物生产疫苗具有很大的优势:一方面植物作为生物反应器能有效的进行翻译后加工;另一方面,利用植物生产疫苗蛋白成本低、易口服、安全性好。转基因植物只表达组分疫苗,不含致病微生物或潜在的致病微生物,对人畜安全,所以由植物表达结核杆菌分泌蛋白,有可能发展成为抗结核的转基因植物疫苗。Tuberculosis is the chronic infection and can contaminate human across communication between mankind and livestock. BCG is currently only commoditied vaccine preventing tuberculosis , effective prevention and cure rate is only 50% though BCG has some prevention and its cure effect has been for 50 years .Tuberculosis Mycobactcrium secreted proteins as subunit vaccine has good immunogenicity, which can induce anti-tuberculosis immunocompetence. Meanwhile plant vaccine is cheap , no side-effect and mass production .Vaccine production by transgenic plants have many advantages： firstly Looking the plants on as biology reactor can have effective process after translation; Secondly, low cost ,easy to take orally, good security .Transgenic plants only express group vaccine and on microorganism causing disease or potential microorganism , which is safe to mankind and livestock, so tuberculosis Mycobactcrium secreted proteins expressed by plants will develop antituberculosis Transgenic plants vaccine.

关 键 词：结核 基因 植物疫苗 

分 类 号：S855.99[农业科学—临床兽医学] S855.2[农业科学—兽医学]