严重型再生障碍性贫血患者血清 IL-2、sIL-2R 水平与免疫抑制治疗关系的研究  

Correlation between the serum levels of interleukin 2 and soluble interleukin 2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients

作　　者：邵宗鸿[1] 陈克奇[1] 陈桂彬[1] 张益枝[1] 王彤[1] 邹尧[1] 周雪丽[1] 周宇[1] 储榆林[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所

出　　处：《中华血液学杂志》1997年第4期180-182,共3页Chinese Journal of Hematology

摘　　要：目的：探索严重型再生障碍性贫血患者自身影响免疫抑制治疗的因素。方法：采用酶联免疫法测定２２例严重型再生障碍性贫血患者治疗前及正常献血者血清中白细胞介素２（ＩＬ－２）和可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）水平。结果：４０．９％和６３．６％的严重型再生障碍性贫血患者血清中ＩＬ－２和ｓＩＬ－２Ｒ水平高于正常人，此组患者对环孢霉素Ａ或（和）抗淋巴细胞球蛋白治疗反应明显优于血清中ＩＬ－２和ｓＩＬ－２Ｒ水平正常或减低者（Ｐ＜０．０５）：ＩＬ－２水平增高者有效率８８．９％，ＩＬ－２水平不高者有效率５３．９％；ｓＩＬ－２Ｒ水平增高者有效率７８．６％，不增高者５０．０％。结论：严重型再生障碍性贫血患者血清中ＩＬ－２和ｓＩＬ－２Ｒ水平明显影响免疫抑制剂疗效，测定其水平对指导严重型再生障碍性贫血的治疗是有意义的。Objective: To explore factors influencing the effectiveness of immunosuppressive therapy in severe aplastic anemia(SAA). Methods: The serum levels of interleukin 2 (IL 2) and soluble IL 2 receptor (sIL 2R) of 22 SAA patients and 15 normal controls were measured by immunoenzyme assay. Results: Comparing with the normal controls,40.9% and 63.6% of the SAA patients had higher serum levels of IL 2 (>840ng/L) and of sIL 2R (>320×10 3 U/L),respectively .Those who had higher IL 2 levels and higher sIL 2R levels got better responses to cyclosporin A(CsA) and CsA plus antilymphocyte globulin (ALG) . Conclusion: The serum levels of IL 2 and sIL 2R were correlated with the responsiveness to immunosuppressive therapy in SAA patients and might be useful for directing treatment.

关 键 词：再生障碍性贫血 白细胞介素 免疫抑制剂 

分 类 号：R556.505[医药卫生—血液循环系统疾病]