谷氨酸信号通路及其在骨力学信号转导通路中潜在的功能  

Glutamate Signaling and its Potential Function of Mechanotransduction in Bone

作　　者：曾强成[1] 张西正[1] 刘洪玲[2] 陈红星[3] 邓继先[3] 

机构地区：[1]军事医学科学院卫生装备研究所 [2]山东德州学院生物系,山东德州253021 [3]军事医学科学院生物工程研究所,北京100071

出　　处：《生物技术通讯》2007年第5期827-829,共3页Letters in Biotechnology

基　　金：国家自然科学基金项目(30470438);山东德州市科委科技发展计划项目(050701)

摘　　要：自在中枢神经系统中发现谷氨酸发挥功能以来,谷氨酸受体及其在突触内膜偶联的信号通路,就成为神经系统研究的重要内容。近年的研究显示,谷氨酸受体及其胞内信号通路在包括骨在内的非神经组织中表达和发挥功能,在骨细胞中有表达谷氨酸受体、转运子的证据,因而有假说认为谷氨酸成了骨中力学信号潜在的转导子,但还缺乏有利的证据支持。简要综述了谷氨酸信号通路及其在骨中的功能,并就其在骨力学信号转导中潜在的功能和作用机制进行了探讨。Since the discovery of its role in the central neural system, glutamate together with its involvement in signalling at synapses has been the subject of many researchers. More recently glutamate signalling is also functional in nonneuronal tissue include bone. Glutamate has been implicated as a mediator of mechanical signalling in bone. Glutamate receptors, transporters and proteins that modulate glutamate release, are all expressed in bone cells. In this review, the evidence for functional glutamate signalling in bone will be summarized and the potential function in mechanotransduction will be highlighted.

关 键 词：谷氨酸信号通路 骨 力学信号转导 

分 类 号：Q25[生物学—细胞生物学]