外加电场对实验性大鼠脊髓损伤作用的研究  

Effect of Electric Fields on Experimental Spinal Cord Injury in Rats

作　　者：邵阳[1] 王永堂[2] 高洁[2] 马海涵[2] 罗治彬[2] 陈恒胜[2] 伍亚民[2] 

机构地区：[1]川北医学院附属医院,四川南充637000 [2]第三军医大学大坪医院野战外科研究所创伤烧伤复合伤国家重点实验室,重庆400042

出　　处：《中国医学物理学杂志》2007年第5期360-362,共3页Chinese Journal of Medical Physics

基　　金：国家自然科学基金资助(No.30300075);军队"十五"青年基金资助(No.01Q106)

摘　　要：目的:探讨脊髓损伤后外加电场(electric fields,EF)对脊髓血流量(spinal cord blod flow,SCBF)及神经功能的影响。方法:Wistar大鼠20只,随机分为对照组(CON组)和EF治疗组(EF组)。Allen's打击法50 gcm(5 g×10 m)致伤大鼠L1～L2段脊髓,给予EF治疗,于伤前、伤后即刻、1、3、6、24 h分别记录T12段脊髓血流量、脊髓感觉诱发电位。术后7、14天行联合行为评分(CBS)。结果:与盐水对照组比较,应用EF后,大鼠SCBF、SEP明显优于CON组(P<0.05)。结论:EF能有效改善损伤早期脊髓微循环,保护脊髓神经功能。Objectives： To investigate the effect of electric fields （EF） on spinal cord blood flow （SCBF） and the function after spinal cord injury（spinal cord injury, SCI）. Methods： A total of 20 Wistar rats were randomly divided into control group（CON） and EF treated group （EF）. EF was given into rats immediately after traumatic injury of the L1-L2 segmental spinal cord was made by using Allen＇s method 50 gcm（5 g× 10 cm）. The SCBF and sensory evoked potential（SEP） of T 12 segment were recorded before injury and at 0, 1, 3, 6, and 24 h after injury. Combined behavioral scores （CBS） were assessed 7 and 14 days after surgery. Results： SCBF and SEP of rats treated with EF were much higher than those of the rats in group CON （P 〈 0.05）. Conclusions： EF can improve the spinal cord blood flow and protect the functions of injured spinal cord.

关 键 词：脊髓损伤 电场 脊髓血流量 诱发电位 

分 类 号：Q64[生物学—生物物理学] R651.2[医药卫生—外科学]