肿节风化学成分研究  

Chemical constituents of Sarcandra glabra

作　　者：黄明菊[1] 李妍岚[1] 曾光尧[1] 袁伟民[1] 谭健兵[1] 谭桂山[1] 周应军[1] 

机构地区：[1]中南大学药学院,长沙410013

出　　处：《中南药学》2007年第5期459-461,共3页Central South Pharmacy

摘　　要：目的研究中药肿节风化学成分,为阐明其抗肿瘤有效成分提供依据。方法利用聚酰胺、Sephadex LH-20,Lipophilic sephadex LH-20柱色谱进行分离,根据化合物的理化性质和光谱数据(IR,UV,1H-NMR,13C-NMR)鉴定其结构。结果从肿节风中分离得到7个化合物,分别鉴定为:迷迭香酸甲酯(Ⅰ),迷迭香酸(Ⅱ),丹参素甲甲酯(Ⅲ),咖啡酸(Ⅳ),3,4-二羟基苯甲酸(Ⅴ),异秦皮啶(Ⅵ),邻苯二甲酸二丁酯(Ⅶ)。结论化合物Ⅰ、Ⅱ、Ⅲ、Ⅳ、Ⅶ为首次从本属植物中得到。Objective To obtain a more comprehensive understanding of the effective anti-tumor components, namely the chemical constituents of Sarcandra glabra （Thunb.） Nakai. Methods The constituents were isolated by a series of column chromatography and their structures were elucidated by physico-chemical properties and spectroscopic analysis Results Seven compounds were isolated and identified as methyl rosmarinate （D, rosmarinic acid （Ⅱ）, methyl 3 , 4-dihydroxyphenyllactate （Ⅲ）, caffeic acid （Ⅳ）, 3, 4-dihydroxybenzoic acid （Ⅴ）, isofraxidin （VD, and dibutyl phthalate （Ⅶ）. Conclusion Compound Ⅱ, Ⅱ, Ⅲ, Ⅳ, and Ⅶ were isolated from Sarcandra genus for the first time.

关 键 词：肿节风 化学成分 酚酸类 

分 类 号：R284.1[医药卫生—中药学]