利培酮与氯氮平对儿童心电图的影响  

Effects of Risperidone and Clozapine on Electrocardiogram(ECG) of Child Respectively

作　　者：王晓云 董速敏 

机构地区：[1]赣州市第三人民医院,江西赣州341000

出　　处：《赣南医学院学报》2007年第4期534-535,547,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨利培酮与氯氮平对儿童心电图的影响。方法:采用随机分组方法,将98例儿童精神分裂症患者随机分为利培酮组50例和氯氮平组48例,治疗8周,分别定期检查心电图,时间分别为治疗前和治疗后第1、2、4、6、8周末,并进行比较分析。结果:治疗前两组心电图均正常。治疗后利培酮与氯氮平对心电图改变的发生率分别为23.6%、42.5%,差异极显著(χ2=19.83,P<0.01)。显著异常时段为第4周末。两组均以窦性心动过速、窦性心律不齐和ST-T改变多见,但利培酮组窦性心动过速和ST-T改变发生率明显低于氯氮平组,而窦性心动过缓和窦性心律不齐明显高于氯氮平组。结论:利培酮对儿童心电图的影响显著低于氯氮平。Objectives： Take a look at the effects of risperidone and clozapine on Electrocardiogram （ECG） of child. Methods： To adopt the random method of dividing into groups ,will 98 regular children Schizophrenic random divide into rispefidone group （50 example） with clrozapine group （48 examples）treatment 8 weeks, inspect electrocardiogram respectively and regularly, before treatment and 1.2.4.6.8 weeks after treatment,ECG were conducted and compared for the 2 groups. Results： Before treatment, ECG of both 2 groups were normal. After treatment, the percentage effect on ECG caused by fispefidone and clozapine were 23.6% .42.5% respectively. The most significant differences existed between fispefidone and clozapine （ X^2 = 19.83, P 〈 0.01 ）. Obvious abnormality occurred at the end of the 4th week. Sinus tachycardia, sinus arrhythmia and ST - T change were common in both the 2 groups, but incidence rate of sinus tachycardia or ST-T change were lower and that of sinus arrhythmia or sinus bradycardia higher in the risperidone than in the clozapine group. Conclusion： The study suggests that the effects of fispefidone on child electrocardiogram （ECG） are less than clozapine.

关 键 词：利培酮 氯氮平 儿童 心电图 

分 类 号：R540.41[医药卫生—心血管疾病]