辛伐他汀对去卵巢骨质疏松大鼠股骨生物力学的影响  

Effect of simvastain on bone biomechanical characteristics in ovariectomized rats

作　　者：简小冲[1] 陈江[1] 黄文秀[1] 杜志斌[1] 

机构地区：[1]福建医科大学附属口腔医院种植中心,福州350002

出　　处：《医用生物力学》2007年第3期255-259,共5页Journal of Medical Biomechanics

基　　金：福建省科技攻关汁划重点项目(编号:2003Y025);福建医科大学教授学术发展基金(JS06104)

摘　　要：目的研究辛伐他汀(Simvastatin,SIM)对去卵巢(OVX)骨质疏松大鼠股骨生物力学性能的影响。方法48只3月龄雌性SD大鼠,随机分成3组,假手术(SHAM)组、OVX组和OVX+SIM组,每组8只。适应性喂养一周后进行手术。术后8周开始给药,OVX+SIM组给予SIM 5mg.kg^(-1)·d^(-1),其余两组用等量生理盐水灌服。用药后第4周每组随机处死半数大鼠,12周后处死剩余大鼠,取股骨进行三点弯曲试验,检测股骨最大载荷、弹性载荷、最大桡度、弹性桡度、弯曲刚度系数、弯曲韧度系数等生物力学性能。结果(1)用药4周,最大载荷:SHAM组较OVX组明显增加(P<0.05);弹性载荷:OVX+SIM组较OVX组明显降低(P<0.05);最大桡度:SHAM组较OVX组明显增加(P<0.05);弯曲韧度系数:OVX+SIM组较OVX组明显增加(P<0.01)。(2)用药12周,最大载荷:OVX+SIM组、SHAM组较OVX组明显增加(P<0.05,P<0.01);弹性载荷:OVX+SIM组较OVX组明显增加(P<0.05);弯曲韧度系数:OVX+SIM组、SHAM组较OVX组明显降低(P<0.05,P<0.01)。(3)用药12周较4周,OVX+SIM组最大载荷、弹性载简明显增加(P<0.01),OVX组弯曲韧度系数明显增加(P<0.01)。结论SIM能促进去势大鼠骨的再建,改变骨的空间微结构和骨组织有机成分和无机成分的比例及结合,随时间的延长能提高股骨的强度。Objective To investigate the effect of simvastain on the biomechanical characteristics of femur in ovariectomized rats. Methods 48 female SD Rats were randomized divided into three groups： Sham-operated group （S）, ovariectomized group （OVX） and Simvastatin ovariectomized rats group （OVX＋SIM）. 8 weeks later, Simvastatin were administered orallywith 5mg·kg^-1·d^-1 to OVX＋SIM group and normal saline to the other two groups. The rats were killed separately 4 weeks and 12 weeks after operation .The femora were taken out for the three-point bending test to measure the maximal loading, flexibility loading, flexibility strain ,maximal strain,coefficient of bending stiffness,coefficient of bending ductility of the femur. Results （1） The maximal loading and the maximal strain of femur in SHAM group was significantly higher than that in the OVX group（P〈0.05） at 4 weeks after treatment. The coefficient of bending ductility of the femur in the OVX＋SIM group was significantly higher than that in the OVX group （P〈0.01） while the the flexibility loading of the femur in OVX＋SIM group was significantly lower than that in the OVX group （P〈0.05） at 4 weeks after treatment. （2） 12 weeks after treatment, the maximal loading of the femur in the OVX＋SIM group or that in the SHAM group was significantly higher than that in the OVX group （P〈0.05, P〈0.01）, the flexibility loading of the femur in the OVX＋SIM group was significantly higher than that in the OVX group （P〈0.05）, the coefficient of bending ductility of the femur in theOVX＋SIM group or that in the SHAM group was significantly lower than that in the OVX group （P〈O.05, P〈O.01 ）; （3） The maximal loading of the OVX＋SIM group, the flexibility loading of the OVX＋SIM groupξ-or the coefficient of bending ductility of the OVX group at 12 weeks after treatment was significant higher than that at 4 weeks after treatment with statistically significant （P〈O.01）. Conclusion Simvastain could affect the

关 键 词：骨质疏松 辛伐他汀 生物力学 

分 类 号：R681.4[医药卫生—骨科学] R318.01[医药卫生—外科学]