新的吡啶杂环硫代磷酸酯类化合物的合成及杀虫活性  

Synthesis and Insecticidal Activity of a Novel Pyridine-heterocyclic Thiophosphate Compounds

作　　者：郑辉[1] 刘运奎[1] 李艳波[2] 肖亮[2] 徐振元[1] 

机构地区：[1]浙江工业大学绿色合成技术国家重点实验室培育基地,杭州310014 [2]上海市农药研究所国家南方农药创制中心上海基地,上海200032

出　　处：《农药学学报》2007年第3期215-219,共5页Chinese Journal of Pesticide Science

基　　金：国家"973"计划(2003CB114400);长三角重大科技联合攻关项目(2004E60056)

摘　　要：为了寻找高活性的新化合物,通过相转移催化反应,在二氯甲烷/水体系中合成了一系列新的吡啶杂环硫代磷酸酯类化合物,其结构均经1H NMR、13C NMR、31P NMR、IR和MS的表征,并通过元素分析确证。室内生物活性测试结果表明,部分化合物表现出较好的杀虫活性,其中化合物3a对苜蓿蚜Aphis medicaginisKoch和化合物3c对东方粘虫Mythimna separate的LC50值分别为1.64和0.73mg/L,与对照药剂毒死蜱的活性相当。In search of novel compounds with high bioactivities, a series of pyridine-heterocyclic thiophosphate compounds were synthesized in CH2 Cl2/H2 O system catalyzed by tetrabutyl ammonium bromide. All compounds were confirmed by ^1 H NMR, ^13 C NMR,^ 31 P NMR, IR, MS and elemental analysis. The bioassay results show that the compounds have good insecticidal activity. The LCs0 value of compound 3a against Aphis medicaginis Koch and 3c against Mythimna separata were 1.64 and 0.73 mg/L, respectively. The control effects were equal to the treatment of chlorpyrifos.

关 键 词：吡啶杂环化合物 硫代磷酸酯 合成 杀虫活性 

分 类 号：O626.32[理学—有机化学] O627.51[理学—化学]