萘普生控释片的处方筛选  

FORMULATION SCREENING OF NAPROXEN CONTROLLED RELEASE TABLETS

作　　者：杨红[1] 李成蓉[1] 邓安平[1] 李颖[1] 刘琼芳[1] 

机构地区：[1]华西医科大学

出　　处：《中国医药工业杂志》1997年第5期214-217,共4页Chinese Journal of Pharmaceuticals

摘　　要：筛选了１４个萘普生控释片处方。其中处方１４，２ｈ累积释放药物１８．０％，６ｈ为４８．６％，１２ｈ为９４．０％，释放速率接近零级动力学，释放速率常数ｋ为０．０７７６ｈ－１，释放ｔ１／２为６ｈ。Among 14 formulations designed, the 14th was the best one:18.0% of naproxen was released in 2 h, 48.6% in 6 h, and 94.0% in 12 h. Its releasing rate in vitro was found to be in accordance with zero order kinetics, and the release rate constant k in vitro was 0.0776 h -1 and t 1/2 of release 6 h.

关 键 词：萘普生 控释片 释放度 

分 类 号：R971.1[医药卫生—药品] R944.9[医药卫生—药学]