天然产物中的抗补体活性成分  

Anti-complementary Agents from Natural Products

作　　者：徐晗[1] 章蕴毅[1] 张建文 陈道峰[1] 

机构地区：[1]复旦大学药学院,上海200032 [2]美国BioCryst药物有限公司生物部门,美国伯明翰35244

出　　处：《中国天然药物》2007年第5期322-332,共11页

基　　金：国家自然科学基金(No30572315);高等学校博士学科点专项科研基金(No20040246079)~~

摘　　要：补体系统的非正常激活会引发类风湿性关节炎、老年性痴呆、急性呼吸窘迫综合征以及系统性红斑狼疮等多种疾病。目前临床上尚无高效、低毒、专一的补体抑制剂。国内外已完成部分天然产物的筛选,发现自然界中广泛存在的某些多糖、黄酮、甾类和萜类化合物具有显著的抗补体活性。本文对天然产物类抗补体活性成分的研究方法、已发现活性化合物的化学结构以及体内外药理研究概况进行综述,并分析了天然产物类补体抑制剂的应用前景。Inappropriate activation of complement is involved in the pathogenesis of many auto-immune disorders, inflammatory diseases and inflammation responses seen in the conditions such as cardiopuhnonary by-pass and bacterial infections. But there is still no desirable therapeutic compound available on the market for complement inhibition. Numerous naturally occurring agents have heen shown to have anti-complementary effects, and they offer the prospect of inexpensive and non-toxic strategies for the therapeutic inhibition of complement. In the present paper, the natural antieomplementary ingredients are summarized and classified according to their chemical nature and complement inhibiting efficacy, especially the future application of them was highlighted. The approaches used to develop the natural occurring anticomplementary agents were also discussed in this report.

关 键 词：补体抑制剂 天然产物 化学结构 药理活性 临床应用 

分 类 号：R967[医药卫生—药理学]