黄山乌头中的二萜生物碱(英文)  

Norditerpenoid Alkaloids from Aconitum carmichaeli var.hwangshanicum

作　　者：赵安幸[1] 彭崇胜[1] 张晨虹[1] 贾伟[1] 

机构地区：[1]上海交通大学药学院,上海200240

出　　处：《中国天然药物》2007年第5期355-356,共2页

基　　金：上海交通大学PRP项目资助(No17006)~~

摘　　要：目的:对黄山乌头中二萜生物碱类化合物进行研究。方法:应用离子交换树脂法提取黄山乌头总生物碱,经色谱法分离、纯化,光谱数据和理化性质确定各化合物的结构。结果:分离得到3个化合物,分别鉴定为海帕乌头碱(Hypaconitine ,1) ,中乌头碱(mesaconitine,2) ,尼奥宁(Neoline,3)。结论:3个化合物均为首次从该植物中得到,双酯型乌头碱(1 ,2)为黄山乌头主要生物碱成分。AIM： To study the diterpenoid alkaloids of the radix of Aconitum carmichaeli var. hwangshanicum. METHOD： The total alkaloids obtained by ion exchange resin were subjected to chromatography to afford three norditerpenoid alkaloids. Their structures were elucidated mainly by spectroscopic methods. RESULTS： Three major compounds： hypaconi- tine （1）, mesaconitine （2）, neoline （3） have been isolated from Aconitum carmichaeli var. hwangshanicum. CONCLUSION： Compounds 1 - 3 have been obtained from Aconitum carmichaeli var. hwangshanicum for the in＇st time. Compounds 1 and 2 containing C（ 14）-benzoate and C（8）-acetate group were major alkaloids in this plant.

关 键 词：黄山乌头 去甲二萜生物碱 

分 类 号：R284.1[医药卫生—中药学]