龙葵药材中澳洲茄碱、澳洲茄边碱的含量测定  

Content Determination of Solasonine and Solamargine in Solanum nigrum

作　　者：李明慧[1] 丁岗 孟兆青 蔡静 刘景晶[1] 

机构地区：[1]中国药科大学生命科学与技术学院,南京210009 [2]江苏省中药质量控制工程技术研究中心,南京211100

出　　处：《中国天然药物》2007年第5期360-362,共3页

摘　　要：目的:寻找可以作为评价龙葵药材质量的指标成分,提高龙葵药材的质量标准。方法:采用柱层析方法分离化学成分,应用光谱法进行结构鉴定,用高效液相色谱法测定其在龙葵药材不同部位的含量。结果:从龙葵药材中分离并鉴定了2个含量较高的甾体类生物碱苷澳洲茄碱(solasonine)和澳洲茄边碱(solamar-gine);建立了龙葵药材中澳洲茄碱、澳洲茄边碱的HPLC含量测定方法。结论:这两种生物碱在龙葵药材中含量较高,可用于龙葵药材的质量控制。AIM：To find the criterion constituents in Solanum nigrum,which can be used to improve the quality of Solanum nigrum. METHODS：Chemical constituents were isolated and purified by chromatographic methods. Structural identification was based on chemical and spectroscopic evidence. HPLC was used for quantitative analysis of Solanum nigrum.RESULTS：Two glycoalkaloids were purified and identified as solasonine and solamargine. An HPLC method for the determination of Solasonine and Solamargine in Solanum nigrum was established. CONCLUSION： Solasonine and solamargine were the main bioactive constituents of Solanum nigrum, which can be used to control the quality of Solanum nigrum.

关 键 词：龙葵 澳洲茄碱 澳洲茄边碱 HPLC 

分 类 号：R284.2[医药卫生—中药学] TQ460.72[医药卫生—中医学]