超排卵周期卵巢低反应患者卵泡液骨形成蛋白-15水平升高  

Women with poor response to ovarian stimulation have increased follicular bone morphogenetic protein-15 levels

作　　者：吴琰婷[1] 陆秀娥[1] 王婷婷[1] 何荣环[1] 徐键[1] 黄荷凤[1] 

机构地区：[1]浙江大学医学院附属妇产科医院,浙江杭州310006

出　　处：《浙江大学学报（医学版）》2007年第5期439-442,共4页Journal of Zhejiang University(Medical Sciences)

基　　金：国家自然科学基金(30471642)资助项目

摘　　要：目的：研究卵泡液中骨形成蛋白-15（BMP-15）的水平及其与超排卵周期卵巢低反应之间的关系。方法：对70例因输卵管性或男性因素不孕而行体外受精-胚胎移植（IVF-ET）的患者，采用本中心常规促超排卵方案，用Western印迹方法测定取卵时各组卵泡液中BMP-15的水平。按取卵时卵泡发育数目不同，将卵巢对超排卵药物的反应分为低反应型（卵泡数≤3）和正常反应型（卵泡数4～13个）。结果：卵泡液中BMP-15的相对光密度（ROD），低反应组高于正常反应组（1．01±0．34VS0．77±0．24，P〈0．01），差异有显著性。结论：卵泡液中高BMP-15水平与促排卵周期卵巢低反应的发生有关。Objective： To evaluate the levels of bone morphogenetic protein-15 （BMP-15） in human follicular fluid （FF） and its association with response to ovarian stimulation. Methods： Western blotting was performed to determine the levels of BMP-15 in FF obtained from follicle aspirates in 70 patients undergoing IVF treatment. According to the response to ovarian stimulation the patients were divided into poor responder group and normal responder group. Results： BMP-15 levels in FF of poor responders were significantly higher than those in normal responders （1.01＋0.34 vs 0. 77＋0.24,P〈0.01）. Conclusion. Increased levels of BMP-15 in FF may be associated with poor response to ovarian stimulation.

关 键 词：卵泡液 超排卵 骨形态发生蛋白质类 卵巢/细胞学 卵巢/代谢 受精 体外 胚胎移植 印迹法 蛋白质 

分 类 号：R714.8[医药卫生—妇产科学]