新冠心苏合滴丸对实验性急性心肌缺血的研究  

Study of Xin Guanxin Suhe Diwan on Experimental Acute Myocardial Ischemia

作　　者：李春香[1] 王文智[1] 李清[1] 郝蕾[1] 

机构地区：[1]河北医科大学中医学院,石家庄050091

出　　处：《河北中医药学报》2007年第3期3-5,13,共4页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省科技厅资助项目:NO0520611034D-15号

摘　　要：目的:对比观察新冠心苏合滴丸对垂体后叶素(Pit)或异丙肾上腺素(ISO)导致的实验性急性心肌缺血的作用。方法:分别采用腹腔注射Pit或ISO的方法复制小鼠实验性急性心肌缺血模型,观察各给药组动物心电图的改变及血清中SOD、MDA含量的变化。结果:两种造模方法复制成功后,新冠心苏合滴丸均可不同程度的改善心电图,提高血清SOD活性,降低MDA含量。结论:新冠心苏合滴丸有对抗Pit或ISO导致的实验性急性心肌缺血作用。Objective:to observe and compare the effect of Xin Guanxin Suhe Diwan on experimental acute myocardial ischemia induced by Pit or ISO. Methods: model rats with experimental acute myocardial ischemia were made by injecting Pit or ISO into abdominal cavity; cardiogram changes of medicine group, SOD and MDA in serum were observed. Results: both kind models made, Xin Guanxin Suhe Diwan could improve the cardiograms to a certain degree, increase SOD activity, and decrease MDA contents. Conclusion: Xin Guanxin Suhe Diwan can resist experimental acute myocardial ischemia induced by Pit or ISO.

关 键 词：新冠心苏合滴丸 心肌缺血 垂体后叶素 异丙肾上腺素 

分 类 号：R289.5[医药卫生—方剂学]