脂蛋白相关磷脂酶A_2水平与冠状动脉病变严重程度的关系  

Relationship between lipoprotein-associated phospholipase A_2 levels and the severity of coronary artery disease

作　　者：夏国志[1] 田国平[1] 雷长城[1] 曾高峰[1] 

机构地区：[1]南华大学附属第二医院心内科,湖南省衡阳市421001

出　　处：《中国心血管病研究》2007年第10期731-733,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨脂蛋白相关磷脂酶A(2Lp-PLA2)水平与冠状动脉(冠脉)病变严重程度的相关性。方法检测344例疑诊为冠状动脉疾病(CAD)患者血浆Lp-PLA2,并行冠脉造影,以病变支数及评分评价冠脉病变程度,并分析与Lp-PLA2水平之间的关系。结果无CAD者(冠脉评分=0分)与CAD者Lp-PLA2水平差异有统计学意义[(211±47)ng/ml与(245±59)ng/ml](u=5.99,P<0.05);不同冠脉病变支数、冠脉评分与Lp-PLA2水平间差异有统计学意义,3支病变和2支病变组均高于1支病变组[(254±66)ng/ml、(247±57)ng/ml和(230±50)ng/ml](F=9.98、H=29.09,均P<0.05);在排除影响因素后,经多元逐步回归分析显示,Lp-PLA2是冠脉病变的危险因子。结论血浆Lp-PLA2水平与冠状动脉病变呈正相关。　Objective To evaluate the association of plasma lipoprotein-associated phospholipase A2（Lp-PLA2） level and the severity of coronary artery disease. Methods 344 subjects with suspected coronary artery disease（CAD） were enrolled in this study who were divided into no CAD group and CAD group according to results of coronary angiography（CAG）, the latter was further divided into subgroups based on the sum of diseased coronary branches. Blood samples for measurement of Lp-PLA2 level were taken before CAG. Patients with CAD were assigned to one of four subgroups according to Lp-PLA2 level with 25,50 and 75 percentile as cut-off points. Results In contrast to no CAD group, plasma Lp-PLA2 level was obviously higher in CAD group[（211±47）ng/ml and （245±59）ng/ml,（u=5.99,P〈0.05）]. Plasma Lp-PLA2 count increased with the number of diseased coronary branches[（254±66）ng/ml,（247±57）ng/ml and （230±50）ng/ml] （F=9.98,H=29.09,P〈0.05）. It was found high Lp-PLA2 count associated of high coronary artery stenosis scores（H=29.09,P〈0.05）. By spearman correlation analysis, the integrated scores of coronary artery stenosis positively correlated with Lp-PLA2 level（r=0.532,P〈0.01）. Multiple stepwise regression analysis indicated Lp-PLA2 count associated with the severity of coronary artery lesions after adjustment for potential confounding variables. Conclusion Advanced Lp-PLA2 level is related to the severity of coronary artery disease.

关 键 词：脂蛋白相关磷脂酶A2 冠状动脉疾病 

分 类 号：R543.3[医药卫生—心血管疾病]