阿托伐他汀对自发性高血压大鼠去外膜颈动脉血管功能的影响  

Effect of atorvastatin on function of carotid artery after adventitia removal in spontaneously hypertensive rats

作　　者：杨浩[1] 吴明[1] 汪俊元[1] 王安才[1] 

机构地区：[1]皖南医学院附属弋矶山医院心内科

出　　处：《中国临床药理学与治疗学》2007年第8期915-919,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:观察阿托伐他汀对自发性高血压大鼠(SHR)去外膜后血管阻力及对去甲肾上腺素(NE)的收缩性的影响。方法:36只16周龄雄性SHR去除一侧颈动脉外膜后,随机分为3组:阿托伐他汀组、缬沙坦组、SHR对照组,分别给药4、8周分两次处死。给药前及给药后每2周测量大鼠尾动脉SBP;测定双侧颈动脉血流量和血管张力。结果:给药4周时,阿托伐他汀组SBP下降,至6、8周时较SHR对照组显著下降(P<0.05,P<0.01);去外膜侧早期血管阻力指数轻度降低,至8周时则大于正常侧;而阿托伐他汀组和缬沙坦组血管阻力指数均较SHR对照组显著减小(P<0.05,P<0.01)。去外膜侧颈动脉对NE的收缩反应在4周和8周时均显著低于正常对照侧(P<0.01);4周时阿托伐他汀组较SHR对照组显著增加双侧颈动脉对NE的最大收缩反应(P<0.05),而8周时较SHR对照组减小。结论:去外膜后早期SHR血管阻力轻度下降,但后期高于正常侧,而阿托伐他汀可显著降低SHR的血管阻力,包括未去外膜血管。去外膜后,SHR的颈动脉环对NE的收缩性显著低于正常对照侧血管。早期阿托伐他汀可提高去外膜血管对NE的收缩反应,但至后期则可降低其对NE的收缩性。AIM： To explore the effect of atorvastatin on the function of carotid artery after adventitia removal in SHR. METHODS： 16-week old male SHR （n = 36） with left carotid artery adventitia removed were randomly divided into 3 groups （n = 12, each）： SHR control group, atorvastatin group, valsartan group and the half rats of each group were put to death at the 4th and 8th weeks respectively. The systolic blood pressure （SBP） was assessed before and after treatment with atorvastatin every 2 weeks. The velocity of carotid artery was detected by electromagnetic rheometer while vasotension changes to NE was measured using a force transducer connected with a polygraph. RESULTS： Compared with SHR control group, the SBP of atorvastatin group began declining at the 4th week , and was reduced significantly at the 6th and 8th weeks （ P 〈 0.05, P 〈 0.01 ）. The resistance index of carotid artery was reduced significantly in atorvstatin group and valsartan group than that in SHR control group （P 〈 0.05, P 〈 0.01）, and it was, at the 4th week, lowered slightly in adventitia removal side than that in normal control side while it was mildly higher at the 8th week, but there was no significant difference between the two sides（ P 〉 0.05）. Vasotension to NE of carotid artery was reduced significantly after adventitia removal （P 〈 0.01）, it was improved by atorvastatin at the 4th week （P 〈 0.01）, but decreased mildly at the 8th week（ P 〈 0.05）. CONCLUSION： Atorvastatin causes a significant reduction of blood pressure in SHR. Adventitia removal makes the vascular resistance of SHR slightly lower at the early stage but higher later, treatment with atorvastatin may lead to decreasement of vascular resistance including the side without adventitia removal. Adventitia removal depresses the vasotension to NE in SHR, the depressed vasotension to NE after adventitia removal can be improved by atorvastatin at the early stage while it can be worsen later.

关 键 词：阿托伐他汀 自发性高血压大鼠 颈动脉 外膜 血管重塑 血管阻力 

分 类 号：R965.2[医药卫生—药理学]