γ-干扰素、腺苷脱氨酶对结核和非结核性胸腔积液的诊断价值  

Diagnostic Significance of Interferon Gamma Concentration,Adenosinase Deaminase Activity in Tuberculous and Nontuberculous Pleural Effusions

作　　者：李铁成[1] 

机构地区：[1]江苏省连云港市第四人民医院,222023

出　　处：《临床肺科杂志》2007年第11期1222-1222,1235,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的联合检测胸腔积液和血清γ-干扰素浓度及腺苷脱氨酶水平,探讨其对结核和非结核性胸腔积液的鉴别诊断价值。方法应用酶联免疫吸附法和速率法,检测46例结核性胸液、42例非结核性胸液及其相应血清中IFN-γ浓度和ADA水平,并与30例对照组比较。结果结核性胸膜炎患者胸液IFN-γ浓度为(497.13±200.79)ng/L,明显高于癌性胸液组(72.16±78.58)ng/L和漏出性胸液组(13.61±5.92)ng/L(P<0.001)。结核性胸膜炎患者胸液ADA水平(54.45±15.33U/L)明显高于癌性胸液组(18.67±16.54)U/L和漏出液组(8.97±1.96)U/L,P<0.001。结论联合检测胸液INF-γ浓度和ADA活性对结核性胸腔积液的鉴别诊断有较高的临床应用价值。Objective To evaluate the clinical usefulness of interferon-gamma and adenosine deaminase in differentiating diagnosis of tuberculous from nontuberoulous pleural effusions. Methods The IFN-γconcentration and ADA activity of 88 cases of tuberculous and nontuberculous pleural effusions were determined by ELISA and enzyme kinetic analytical method respectively. 30 cases of control group were also studied. Results The IFN-γconcentration in the tuberculous pleural effusion group was （497.13 ± 200. 79 ） ng/L, which was significantly higher than that in the malignant group （72.16 ±78.58 ） ng/L, P 〈 0. 001 ）. The ADA level （ 54. 45 ±15.33 ） U/ L in the tuberculous pleurat effusion group was significantly higher than that in the malignant group （18.67 ±16. 54） U/L, P 〈 0. 001. Conclusions The results indicated that simultaneous measurement of IFN-γconcentration and ADA activity in pleural effusions is a useful diagnostic method for differentiating tuberculous pleurisy from nontuberculous pleurisy.

关 键 词：结核 胸膜炎 干扰素 腺苷脱氨酶 诊断 

分 类 号：R521.7[医药卫生—内科学] R561[医药卫生—临床医学]