经导管肺动脉瓣膜植入的实验研究  

Experiment study of open transcatheter replacement of pulmonary valves

作　　者：宗刚军[1] 白元[1] 吴弘[1] 赵仙先[1] 姜海滨[1] 邹毅清[2] 张浩[3] 秦永文[1] 

机构地区：[1]第二军医大学长海医院心内科,200433 [2]第二军医大学长海医院麻醉科,200433 [3]第二军医大学长海医院胸心外科,200433

出　　处：《介入放射学杂志》2007年第9期623-626,共4页Journal of Interventional Radiology

基　　金：国家高科技研究发展计划(863计划)(NO.2006AA02Z4D7)

摘　　要：目的探讨经导管植入带瓣膜支架置换肺动脉瓣的可行性。方法以新鲜的羊心包为材料,予0.6%戊二醛浸泡36h后缝合在瓣膜环上,将其固定在镍钛形状记忆合金自膨胀支架上,制成带瓣膜肺动脉支架。选择体重为(23.5±3.1)kg的健康羊8只,通过开胸,穿刺右心室前壁,将带瓣膜支架经导管送到肺动脉,植入肺动脉瓣处,置换自身肺动脉瓣膜。结果8只羊中即时成功7只,术后即刻以及90d的影像学以及血流动力学检测支架的位置及瓣膜功能良好,无相关并发症。结论直视下经导管植入肺动脉瓣膜是可行的。Objective To determine the feasibility of transcatheter pulmonary valve replacement in sheeps. Methods A fresh sheep pericardium was cross-linked with a 0.6% glutaraldehyde solution for 36 hours and then sutured on a valvular ring and in turn onto a newly designed nitinol self-expandable stent. Sheeps of（23.5 ± 3.1） kg body weight were chosen. Under general anesthesia and thoracotomy, the device was delivered into the native pulmonary valve of the sheeps via the anterior wall of right ventricle by catheter using standard stent-placing techniques. Results Seven devices were successfully delivered at the desired position in 8 sheeps with no complications. Angiographic and hemodynamic studies confirmed the stents at correct position with competent valvular junction immediately and 90 days after the procedure. Conclusions Implantation of a nitinol self-expandable stentt at the pulmonary valve position is feasible in sheeps though a transcatheter approach.（J Intervent Radiol, 2007, 16： 623-626）

关 键 词：开胸 经导管 肺动脉瓣 置换 

分 类 号：R542.54[医药卫生—心血管疾病]