老年肺心病急性加重期血小板参数的变化与高凝状态的研究  

Platelet Parameter and Hypercoagulable State in Elderly Patients with Exacerbation of Chronic Cor Pulmonale

作　　者：李冬艳[1] 闫薇[1] 

机构地区：[1]山西医科大学第一医院

出　　处：《中西医结合心脑血管病杂志》2007年第10期927-928,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨老年肺心病急性加重期血小板4项分析参数的变化及对机体凝血功能的影响。方法分别测定40例老年肺心病急性加重期病人、37例经治疗后的缓解期病人及35名健康老年人的血小板4项参数值,包括血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)。结果老年肺心病急性加重期病人PLT及PCT显著低于经治疗后的缓解期病人及健康老年人(P<0.01);而MPV,PDW则显著增高(P<0.05)。结论老年肺心病急性加重期可通过多种机制引起血小板参数的变化,进而造成机体高凝状态,是血栓及弥散性血管内凝血(DIC)形成的基础,同时对临床判断肺心病的病情及预后有重要意义。Objective To study the platelet parameters and blood clotting function in elderly patients （pts） with exacerbation of chronic cor pulmonale. Methods The PLT, MPV,PCT and PDW in 40 pts with exacerbation of chronic cor pulmonale, 37 pts with stable chronic cot pulmonale and 35 health people were determined and compared. Results The counts of PLT and PCT in pts with exacerbation of chronic cor pulmonale were significantly lower than that in pts with stable chronic cor pulmonale and that in health people. The PDW and MPV in pts with exacerbation of chronic cor pulmonale were significantly higher than that in pts with stable chronic cor pulmonale and that in health people. Conclusion There were platelet parameter changes in elderly pts with exacerbation of chronic cor pulmonale. This would result in hypereoagulable state and as a prognostic factor of elderly pts with exacerbation of chronic cor pulmonale.

关 键 词：老年肺心病 血小板压积 血小板计数 

分 类 号：R541.5[医药卫生—心血管疾病] R256.2[医药卫生—内科学]