血压平对自发性高血压大鼠血管重塑的作用  

Xuyaping Reversing Vascular Remodeling in Spontaneous Hypertension Rats

作　　者：柯于鹤[1] 屈静[2] 柯于麟 魏清兰[4] 胡有志[5] 李大锋[5] 

机构地区：[1]湖北省武汉市第一医院 [2]武汉大学人民医院 [3]湖北省阳新县人民医院 [4]湖北中医学院 [5]湖北省中医院

出　　处：《中西医结合心脑血管病杂志》2007年第10期955-958,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：武汉市卫生局基金资助项目[武卫(2002)第210号]

摘　　要：目的观察复方中药血压平对自发性高血压大鼠(SHR)血压、血清一氧化氮(NO)含量及动脉血管重塑的影响,并探讨其作用机制。方法将SHR30只随机分为5组,每组6只,分别为SHR对照组、血压平低剂量组、血压平中剂量组、血压平高剂量组、达爽对照组,另随机选6只WKY大鼠作为对照组。测定血压及血清中NO含量,解剖分离其主动脉,观察其形态,测定动脉管壁与腔径之比。结果血压平可降低SHR血压,升高血清NO含量,与SHR对照组相比有统计学意义(P<0.01),且与药物剂量相关;血压平高剂量组优于达爽对照组(P<0.05)。结论血压平有降压及逆转高血压大鼠血管重塑的作用。Objective To observe the influence of Xuyaping on blood pressure, NO content in blood serum and vascular remodeling in spontaneous hypertension rats. Methods Thirty rats with spontaneous hypertension were divided into five groups randomly with 6 rats in each group： Control group, low dosage Xuyaping group, medium dosage Xuyaping group, large dosage Xuyaping group, Dashuang control＇ group. Blood pressure and NO content in serum were tested. Aorta shape and ratio of the aorta wall and the cavity diameter were analyzed. Results Xuyaping could reduce the blood pressure in rats with spontaneous hypertension and elevate the NO content in blood serrum. Con clusion Xuyaping could lower blood presssure and reverse vascular remodeling in rats with Hypertension.

关 键 词：血压平 自发性高血压 一氧化氮 血管重塑 

分 类 号：R285.5[医药卫生—中药学]