Comparable investigation in dopamine transporters with ^(99m)Tc-TRODAT-1 and ^(131)I-FP-CIT SPECT in Parkinson's disease patients  

作　　者：LIU Congjin LIU Xingdang ZHANG Guangming LI Ding WANG Jian YANG Liqin JIANG Yuping 

机构地区：[1]Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China [2]Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China

出　　处：《Nuclear Science and Techniques》2007年第4期232-236,共5页核技术（英文）

基　　金：National "Tenth Five" Scientific Technique Research Plan Project (2001BA702B02)

摘　　要：Dopamine transporter (DAT) mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson's disease (PD). The relationship between them was also evaluated. The results suggested that 99mTc-TRODAT-1 SPECT and 131I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The 99mTc-TRODAT-1 image is more accurate and clearer compared with 131I-FP-CIT.Dopamine transporter （DAT） mediates the regulation of dopaminergic function. Two agents of TRODAT-1 and FP-CIT were observed in evaluating DAT change of Parkinson＇s disease （PD）. The relationship between them was also evaluated. The results suggested that ^99mTc-TRODAT-1 SPECT and ^131I-FP-CIT SPECT may serve as sensitive and objective in vivo markers to reflect the severity of PD. The ^99mTc-TRODAT-1 image is more accurate and clearer compared with ^131I-FP-CIT.

关 键 词：帕金森病 多巴胺输送 ^99MTC-TRODAT-1 SPECT 131I-FP-CIT SPECT 超声影像学 

分 类 号：R445[医药卫生—影像医学与核医学] R445.6[医药卫生—诊断学]