肾移植前胃镜下胃黏膜病变和幽门螺杆菌感染与血清胃泌素关系的探讨  

Relationship among gastric mucosal lesions of patients before renal transplantations infection of Helicobacter pylori and serum gastrin

作　　者：于丰彦[1] 陈向阳[2] 祁力平[2] 曾霞飞[2] 杨彩玲[2] 周福生[1] 

机构地区：[1]广州中医药大学脾胃研究所,广东广州510010 [2]广州中医药大学祈福医院,广东广州511495

出　　处：《中国内镜杂志》2007年第9期911-913,共3页China Journal of Endoscopy

摘　　要：目的探讨101例肾移植前尿毒症患者胃镜下黏膜病变、Hp感染与血清胃泌素、血尿素氮、肌酐的关系。方法对101例临床确诊为尿毒症的合格病例肾移植前分别进行胃镜检查、Hp检测、血清胃泌素和其他常规检查并对检查结果进行统计学分析。结果101例尿毒症患者均存在不同程度的黏膜病变,胃黏膜病变的严重程度与血尿素氮、肌酐成正比。在合并有糜烂、溃疡、息肉等病变时血清胃泌素均有明显升高,与未合并上述病变的病例组比较差异有显著性。结论Hp感染可以降低胃黏膜的抵抗力,但Hp感染不是尿毒症胃黏膜病变的主要原因。胃黏膜糜烂、溃疡、息肉/息肉样病变患者的血清胃泌素水平明显升高,提示高胃泌素血症可能是尿毒症胃黏膜病变的主要病因。[Objective] To explore the relationship among gastric mucosal lesions, helicobacter pylori （Hp） infection, serum gastrin, blood urea nitrogen and serum creatinine in 101 urinemia patients before renal transplantations patients. [Method] 101 clinical definited uraemic patients were respectively carried out with gastroscopy, Hp test, serum gastrin and other routine examinations before renal transplantations. All of the results received statistical analysis. [Result] All of the patients suffered from different degrees gastric mucosal lesions, and the degree was in direct proportion with blood urea nitrogen and serum creatinine. Serum gastrin obviously uprose when there was erosion, ulcer, polyp, ect. There was a significant difference between the group above-mentioned and the group without such kinds of combinations. [Conclusion] Hp infection can degrade gastric mucosa＇s resistance, but it isn＇t the main cause of uraemic gastric mucosal lesion. Serum gastrin obviously upresed when mucosal lesions with erosion, ulcer, polyp, ect. However, Hypergastrinemia may be the main cause of uraemic gastric mucosal lesion.

关 键 词：尿毒症 胃镜下胃黏膜病变 幽门螺杆菌感染 血清胃泌素 

分 类 号：R692[医药卫生—泌尿科学]