缬沙坦与赖诺普利治疗原发性高血压的疗效和安全性的比较研究  

COMPARISON OF THE CURATIVE EFFECTS AND SAFETY OF VALSARTAN AND LISINOPRIL IN TREATING ESSENTIAL HYPERTENSION

作　　者：赵广娟[1] 

机构地区：[1]临沂市人民医院,山东临沂276003

出　　处：《山东医学高等专科学校学报》2007年第5期351-354,共4页Journal of Shandong Medical College

摘　　要：目的研究缬沙坦降压疗效及安全性并与赖诺普利相比较。方法将60例1.2级原发性高血压患者随机分为缬沙坦组(A组),赖诺普利组(B组),经2w冲洗期后,分别给予缬沙坦80mg/d,赖诺普利10mg/d,口服治疗4w,全部病例治疗前后偶测血压(CBP)并行血脂、血糖、尿素氮、肌酐、转氨酶、心率测定。两组中各选10例治疗前后行24h动态血压测定(ABPM)。结果两组降压总有效率CBP分别为80.64%和65.52%(P>0.05)。ABPM分别为70%和60%,两组比较无显著差异(P>0.05)T:P Ratio(SBP分别为72.6%、68.4%,DBP分别为69.0%、60.4%)两组比较无显著差异(P>0.05)。两组血脂、血糖、尿素氮、肌酐、转氨酶以及心率均无明显变化。A组中发生不良反应1例,B组中发生不良反应3例。结论缬沙坦80mg/d能有效地控制血压,不良反应轻,安全耐受性好。Objective To compare the curative effects and safety ot vatsartan and lisinopril Methods 60 cases of essential hypertension of Grade One and Grade Two were classified into Group A treated with 80mg of valsartan a day and Group B treated with 10mg of lisinopril a day for four weeks. The clinical blood pressure（CBP） ,serum lipid, blood glucose, urea nitrogen, creatinine, transaminase and heart rate were examined before and after treatments. 10 cases from Coup A and another 10 cases from Group B received 24-hour ambulatory blood pressure monitoring（ABPM）. Results The curative effects in Group A and Group B were 80.64% and 65.52% respectively（ P 〉0.05）.The ABPM was 70% in Group A and 60% in Group B（ P 〉0.05）.The ratio of T and P was 72.6% in Group A and 68.4% in Group B. DBP in Group A was 69.0% and 60.4% in Group B（ P 〉0.05）. No significant differences were found in the two groups in terms of blood lipid, blood glucose, urea nitrogen. Side effects occurred in one case in Group A and 3 in Group B. Conclusion Valsartan can effectively control blood pressure without causing serious side effects.

关 键 词：高血压 血压监测 缬沙坦 赖诺普利 

分 类 号：R544.1[医药卫生—心血管疾病]