病毒性肝炎患者血清转化生长因子-β1活性及其与肝纤维化的关系  

Serum TGF-β1 activity in patients with viral hepatitis and its relation with hepatic fibrosis

作　　者：张立煌[1] 方海林[1] 裘云庆[1] 姚航平[1] 李敏伟[1] 刘克洲[1] 

机构地区：[1]杭州浙江医科大学传染病研究所,310006

出　　处：《中华传染病杂志》1997年第2期82-84,共3页Chinese Journal of Infectious Diseases

摘　　要：为了探讨转化生长因子 -β1( TGF-β1)在肝纤维化发病机制中的作用 ,采用 MV1LU细胞生长抑制 MTT法 ,检测 10 8例病毒性肝炎患者血清 TGF-β1活性 ,同时用放免法检测血清前 型胶原( PC )、透明质酸 ( HA)、层粘蛋白 ( LN)的含量 ,结果表明各型肝炎患者 TGF- β1活性较正常对照都明显增高 ( P<0 .0 1)。随病情的发展 ,TGF- β1活性逐渐增高 ,PC 、HA、LN含量也明显增加 ,各组间差异均有显著性 ( P<0 .0 1)。除肝癌组外 ,TGF- β1活性与 PC 、HA、L N含量间呈正相关 ( r分别为 0 .65、0 .65、0 .60 ,P<0 .0 1)。提示 TGF- β1活性较好地反映肝纤维化进展状况 。To study the role of transforming growth factor β1 (TGF β1) in the pathogenesis of hepatic fibrosis, serum TGF β1 activity of 108 patients with viral hepatitis were analysed by the modified MV1LU cell growth inhibitory assay, serum procollagen type Ⅲ (PCⅢ),hyaluronic acid (HA) and laminin (LN) concentrations were likewise measured by radioimmunoassay. The results showed the TGF β1 activity was significantly higher in various types of viral hepatitis as compared with the normal controls (P<0 01). The TGF β1 activity as well as serum PCⅢ. HA and LN levels increased gradually with the progress of the diseases. The difference was significant among various groups (P<0 01), except for the hepatocelluar carcinoma group. There existed possitive correlation between the serum TGF β1 activity PCⅢ、HA and LN levels (r=0 65, 0 65, 0 60, respectively, P<0 01). The results suggested that TGF β1may be an important modulating factor in the process of hepatic fibrosis and might be used as an index for evaluating the progress of liver fibrosis.

关 键 词：病毒性肝炎 转化生长因子 肝纤维化 病因 

分 类 号：R512.606[医药卫生—内科学] R575.202[医药卫生—临床医学]