2-(取代氨基硫代甲酰基)-3,4,5,6-四氢嘧啶的合成  

Synthesis of 2-(Substituted aminothiocarbonyl)-3,4,5,6-tetrahydropyrimidines

作　　者：刘玮炜[1] 唐丽娟[1] 曾艳霞[1] 王玲[1] 赵跃强[1] 陈克潜[2] 陆忠娥[2] 

机构地区：[1]淮海工学院化工系,连云港222005 [2]苏州大学化学系,苏州215123

出　　处：《有机化学》2007年第10期1285-1287,共3页Chinese Journal of Organic Chemistry

基　　金：江苏省海洋生物技术重点建设实验室基金(No.2006HS014);淮海工学院学科建设基金(No.XK200309)资助项目

摘　　要：以N,N'-二取代二硫代草酰胺与1,3-丙二胺在DMSO中进行缩合反应,合成了一系列2-取代氨基硫代甲酰基-3,4,5,6-四氢嘧啶,反应在2h内完成,产率56%～76%.产物结构经元素分析,IR,1HNMR及MS确证.A series of 2-substituted aminothiocarbonyl-3,4,5,6-tetrahydropyrimidine compounds were synthesized by the condensation reaction of N,N′-disubstituted dithiooxamide with 1,3-propylenediamine in DMSO. The reactions were completed in 2 h with the yields of 56%-76%. The structures of the products were established by elemental analysis, IR, ^1H NMR and MS spectra.

关 键 词：N N′-二取代二硫代草酰胺 1 3-丙二胺 2-(取代氨基硫代甲酰基)-3 4 5 6-四氢嘧啶 合成 

分 类 号：TQ253[化学工程—有机化工]