含呋喃环双酰肼类化合物的合成及杀虫活性研究  

Synthesis and Insecticidal Activity of Diacylhydrazine Containing Furan

作　　者：崔紫宁[1] 王振[1] 李映[1] 周心玉[1] 凌云[1] 杨新玲[1] 

机构地区：[1]中国农业大学理学院应用化学系,北京100094

出　　处：《有机化学》2007年第10期1300-1304,共5页Chinese Journal of Organic Chemistry

基　　金：国家"十五"科技攻关(No.2004BA308A22-11);国家重点基础研究发展计划(973计划)(No.2003CB114400)资助项目

摘　　要：为发现新的昆虫生长调节剂,经邻、间、对氯单取代苯基呋喃甲酰氯与取代苯甲酰肼反应得到15个未见文献报道的含呋喃环双酰肼类化合物,其结构均通过了IR,1HNMR和元素分析确认.初步生测结果表明R2为对氯取代的目标化合物对3龄粘虫(Mythimna separate)表现出较好或中等的杀幼虫活性.其中化合物Io和Ij在药剂浓度为0.1%时,对粘虫幼虫的死亡抑制率分别为85%和55%,并对幼虫蜕皮有一定的抑制作用.而大部分目标化合物在药剂浓度为0.05%时,对豆蚜(Aphis fabae)和棉红蜘蛛(Tetranchus urticae)杀虫活性不明显.15 novel diacylhydrazine derivatives containing furan were synthesized by the reaction of 5-（ortho-, meta- or para-Cl） substituted benzoyl-2-furancarbonyl chloride with substituted benzohydrazide in anhydrous dichloromethane under reflux. Their structures were confirmed by IR, ^1H NMR spectra and elemental analysis. The preliminary bioassay showed that some title compounds exhibit good or moderate larvicidal activity to the Mythimna separata and induce a premature, abnormal, and lethal larval molt. At the concentration of 0.1%, compounds Io and Ij showed respectively 85% and 55% larvicidal activities to armyworm （Mythimna separate）. Most of the title compounds showed lower activity to the Aphisfabae and Tetranchus urticae at the concentration of 0.05%.

关 键 词：昆虫生长调节剂 双酰肼化合物 呋喃 蜕皮 

分 类 号：TQ450[化学工程—农药化工]